Reproductive BioMedicine Online
Volume 19, Issue 5 , Pages 631-637, November 2009

Follicular-fluid anti-Mullerian hormone concentrations are predictive of assisted reproduction outcome in PCOS patients

  • Recai Pabuccu

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine, Ufuk University, Ankara, Turkey
    • ,
  • Cemil Kaya

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine, Ufuk University, Ankara, Turkey
    • Corresponding Author InformationCorrespondence:
    • ,
  • Gamze Sinem Cağlar

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine, Ufuk University, Ankara, Turkey
    • ,
  • Efser Oztas

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine, Ufuk University, Ankara, Turkey
    • ,
  • Hakan Satiroglu

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine, Ankara University, Ankara, Turkey

Received 20 November 2008; received in revised form 28 April 2009; accepted 3 June 2009. published online 02 August 2010.

Declaration: The authors report no financial or commercial conflicts of interest.

Abstract 

Serum anti-Mullerian hormone (AMH) concentrations constitute a sensitive marker for ovarian ageing. In addition, concentrations of AMH in the follicular fluid constitute a useful marker of embryo implantation in assisted reproduction cycles. The present study measured serum and follicular-fluid AMH concentrations on the day of oocyte retrieval. These data showed that clinical pregnancy rates (25.0, 34.1 and 42.1%, respectively, P<0.001), embryo implantation rates (24.3, 35.0 and 44.4%, respectively, P<0.001) and fertilization rates (59.2, 70.9 and 79.5%, respectively, P<0.001) were markedly different among the low, moderate and high follicular-fluid AMH groups but not among the different serum AMH concentration groups. Follicular-fluid AMH concentrations were negatively correlated with follicular-fluid oestradiol concentrations. The results of this study suggest that follicular-fluid AMH concentration on the day of oocyte retrieval would appear to better reflect the reproductive outcome in PCOS patients undergoing assisted reproduction.

Keywords: AMH, assisted reproduction cycles, follicular fluid, PCOS

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 Dr Recai Pabuccu obtained his medical degree in 1975 from Istanbul University Faculty of Medicine, Turkey. After he completed his obstetrics and gynaecology residency, he worked as a clinical fellow in Reproductive Endocrinology and Infertility at the University of British Colombia, Canada. He has published more than forty articles in the field of assisted reproductive technologies and reproductive surgery. Professor Pabuccu is Director of the Department of Obstetrics and Gynecology, Ufuk University, Faculty of Medicine.Dr Recai Pabuccu

PII: S1472-6483(09)00062-5

doi:10.1016/j.rbmo.2009.06.010

Reproductive BioMedicine Online
Volume 19, Issue 5 , Pages 631-637, November 2009

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