Reproductive BioMedicine Online
Volume 19, Issue 6 , Pages 808-815 , December 2009

Apoptosis in normal ovaries of women with and without endometriosis

  • Raffaella Depalo

      Affiliations

    • Centre of Pathophysiology of Human Reproduction and Gametes Cryopreservation, Department of Gynaecology, Obstetrics and Neonatology, University of Bari, Piazza Giulio Cesare, 11-70124 Bari, Italy
    • RD and AC contributed equally to this study.
  • ,
  • Aldo Cavallini

      Affiliations

    • Laboratory of Biochemistry, National Institute for Digestive Diseases ‘Saverio de Bellis’ via Turi, 27-70013 Castellana Grotte, Bari, Italy
    • RD and AC contributed equally to this study.
  • ,
  • Filomenamila Lorusso

      Affiliations

    • Centre of Pathophysiology of Human Reproduction and Gametes Cryopreservation, Department of Gynaecology, Obstetrics and Neonatology, University of Bari, Piazza Giulio Cesare, 11-70124 Bari, Italy
    • Corresponding Author InformationCorrespondence:
  • ,
  • Emma Bassi

      Affiliations

    • Centre of Pathophysiology of Human Reproduction and Gametes Cryopreservation, Department of Gynaecology, Obstetrics and Neonatology, University of Bari, Piazza Giulio Cesare, 11-70124 Bari, Italy
  • ,
  • Ilaria Totaro

      Affiliations

    • Centre of Pathophysiology of Human Reproduction and Gametes Cryopreservation, Department of Gynaecology, Obstetrics and Neonatology, University of Bari, Piazza Giulio Cesare, 11-70124 Bari, Italy
  • ,
  • Andrea Marzullo

      Affiliations

    • Department of Pathologic Anatomy, University of Bari, Piazza Giulio Cesare, 11-70124 Bari, Italy
  • ,
  • Stefano Bettocchi

      Affiliations

    • Centre of Pathophysiology of Human Reproduction and Gametes Cryopreservation, Department of Gynaecology, Obstetrics and Neonatology, University of Bari, Piazza Giulio Cesare, 11-70124 Bari, Italy
  • ,
  • Luigi Selvaggi

      Affiliations

    • Centre of Pathophysiology of Human Reproduction and Gametes Cryopreservation, Department of Gynaecology, Obstetrics and Neonatology, University of Bari, Piazza Giulio Cesare, 11-70124 Bari, Italy

Received 11 December 2008 ,Revised 17 March 2009 ,Accepted 17 August 2009.

References 

  1. Al-Azemi M, Bernal AL, Steele J, et al. Ovarian response to repeated controlled stimulation in in-vitro fertilization cycles in patients with ovarian endometriosis. Human Reproduction. 2000;15:72–75
  2. American Society for Reproductive Medicine. Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertility and Sterility. 1997;67:817–821
  3. Béliard A, Noël A, Foidart JM. Reduction of apoptosis and proliferation in endometriosis. Fertility and Sterility. 2004;82:80–85
  4. Canis M, Pouly JL, Tamburro S, et al. Ovarian response during IVF-embryo transfer cycles after laparoscopic ovarian cystectomy for endometriotic cysts of >3cm in diameter. Human Reproduction. 2001;16:2583–2586
  5. Depalo R, Nappi L, Loverro G, et al. Evidence of apoptosis in human primordial and primary follicles. Human Reproduction. 2003;18:2678–2682
  6. Dmowski WP, Ding J, Shen J, et al. Apoptosis in endometrial glandular and stromal cells in women with and without endometriosis. Human Reproduction. 2001;16:1802–1808
  7. Eskenazi B, Warner ML. Epidemiology of endometriosis. Obstetrics and Gynecology Clinics of North America. 1997;4:235–258
  8. Gebel HM, Braun DP, Tambur A, et al. Spontaneous apoptosis of endometrial tissue is impaired in women with endometriosis. Fertility and Sterility. 1998;69:1042–1047
  9. Gougeon A. Regulation of ovarian follicular development in primates: facts and hypotheses. Endocrine Review. 1996;17:121–155
  10. Harada T, Kaponis A, Iwabe T, et al. Apoptosis in human endometrium and endometriosis. Human Reproduction Update. 2004;10:29–38
  11. Harada M, Suganuma N, Furuhashi M, et al. Detection of apoptosis in human endometriotic tissues. Molecular Human Reproduction. 1996;2:307–315
  12. Hussein MR. Apoptosis in the ovary: molecular mechanisms. Human Reproduction Update. 2005;11:162–177
  13. Jones RK, Searle RF, Bulmer JN. Apoptosis and bcl-2 expression in normal human endometrium, endometriosis and adenomyosis. Human Reproduction. 1998;13:3496–3502
  14. Kaplan CR, Eddy CA, Olive DL, et al. Effect of ovarian endometrioma on ovulation in rabbits. American Journal of Obstetrics and Gynecology. 1989;160:40–44
  15. Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. British Journal of Cancer. 1972;26:239–257
  16. Linsalata M, Giannini R, Notarnicola M, et al. Peroxisome proliferator-activated receptor gamma and spermidine, spermine N1-acetyltransferase gene expressions are significantly correlated in human colorectal cancer. BMC Cancer. 2006;6:191–197
  17. Maneschi F, Marasá L, Incandela S, et al. Ovarian cortex surrounding benign neoplasms: a histologic study. American Journal of Obstetrics and Gynecology. 1993;169:388–393
  18. Metalliotakis IM, Cakmak H, Mahutte N, et al. Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility. Fertility and Sterility. 2007;88:1568–1572
  19. Nargund G, Cheng WC, Parson J. The impact of ovarian cystectomy on ovarian response to stimulation during in-vitro fertilization cycles. Human Reproduction. 1996;11:81–83
  20. Nezhat FR, Kalir T. Comparative immunohistochemical studies of endometriosis lesions and endometriotic cysts. Fertility and Sterility. 2002;78:820–824
  21. Nezhat F, Datta MS, Hanson V, et al. The relationship of endometriosis and ovarian malignancy: a review. Fertility and Sterility. 2008;90:1559–1570
  22. Nezhat F, Cohen C, Rahaman J, et al. Comparative immunohistochemical studies of bcl-2 and p53 proteins in benign and malignant ovarian endometriotic cysts. Cancer. 2002;94:2935–2940
  23. Nezhat F, Nezhat C, Allan CJ, et al. Clinical and histologic classification of endometriomas. Implications for a mechanism of pathogenesis. Journal of Reproductive Medicine. 1992;37:771–776
  24. Nisolle M, Donnez J. Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities. Fertility and Sterility. 1997;68:585–596
  25. Somigliana E, Ragni G, Benedetti F. Does laparoscopic excision of endometriotic ovarian cysts significantly affect ovarian reserve? Insights from IVF cycles. Human Reproduction. 2003;18:2450–2453
  26. Sot B, Freund SM, Fersht AR. Comparative biophysical characterization of p53 with the pro-apoptotic BAK and the anti-apoptotic BCL-xL. Journal of Biology and Chemistry. 2007;282:29193–29200
  27. Sugunama N, Harada M, Furuhashi M, et al. Apoptosis in human endometrial and endometriosis tissues. Hormone Research. 1997;48(suppl. 3):42–47
  28. Vaskivuo TE, Anttonen M, Herva R. Survival of human ovarian follicles from fetal to adult life: apoptosis, apoptosis-related proteins, and transcription factor GATA-4. Journal of Clinical Endocrinology and Metabolism. 2001;86:3421–3429
  29. White E. Life, death, and the pursuit of apoptosis. Genes and Development. 1996;10:1–15

 Professor Luigi E Selvaggi is Chairman of the Department of Gynaecology, Obstetrics and Neonatology, University Hospital Policlinico, Bari, Italy and Ordinary Professor of Obstetrics and Gynaecology, University of Medical Science, Bari. He is past President of the Italian Society of Perinatal Medicine (1998–2002) and has served on its Board of Directors for several years. He has published widely, is an ad-hoc reviewer for various journals and is a member of numerous local and national committees and boards. In 2000, he set up an IVF Unit within his Department that quickly reached high quality standards and now represents a referral centre in this area.Prof Luigi E Selvaggi

PII: S1472-6483(09)00088-1

doi: 10.1016/j.rbmo.2009.09.024

Reproductive BioMedicine Online
Volume 19, Issue 6 , Pages 808-815 , December 2009