Reproductive BioMedicine Online
Volume 20, Issue 1 , Pages 68-74 , January 2010

External quality control for embryology laboratories

  • Jose Antonio Castilla

      Affiliations

    • Human Reproduction Unit, Hospital Virgen de las Nieves, 18014 Granada, Spain
    • Sperm Bank CEIFER, Granada, Spain
    • Programa de Control de Calidad Externo para el Laboratorio de Reproducción de la Asociación para el Estudio de la Biología de la Reproducción (ASEBIR), Madrid, Spain
    • Corresponding Author InformationCorresponding author.
    • ,
  • Rafael Ruiz de Assín

      Affiliations

    • Human Reproduction Unit, Hospital Virgen de las Nieves, 18014 Granada, Spain
    • ,
  • Maria Carmen Gonzalvo

      Affiliations

    • Human Reproduction Unit, Hospital Virgen de las Nieves, 18014 Granada, Spain
    • ,
  • Ana Clavero

      Affiliations

    • Human Reproduction Unit, Hospital Virgen de las Nieves, 18014 Granada, Spain
    • ,
  • Juan Pablo Ramírez

      Affiliations

    • Sperm Bank CEIFER, Granada, Spain
    • Programa de Control de Calidad Externo para el Laboratorio de Reproducción de la Asociación para el Estudio de la Biología de la Reproducción (ASEBIR), Madrid, Spain
    • ,
  • Francisco Vergara

      Affiliations

    • Sperm Bank CEIFER, Granada, Spain
    • Programa de Control de Calidad Externo para el Laboratorio de Reproducción de la Asociación para el Estudio de la Biología de la Reproducción (ASEBIR), Madrid, Spain
    • ,
  • Luis Martínez

      Affiliations

    • Human Reproduction Unit, Hospital Virgen de las Nieves, 18014 Granada, Spain

Received 28 July 2008 ,Revised 13 October 2008 ,Accepted 10 September 2009.

References 

  1. Alvarez C, Castilla JA, Ramírez JP, et al. External quality control program for semen analysis: Spanish experience. J. Assist. Reprod. Genet. 2005;22:379–387
  2. American Association of Bioanalysts 2007 Proficiency Testing Service. Available at http://www.aab-pts.org/Stats [accessed October 2009].
  3. American Association of Bioanalysts 2008 Proficiency Testing Service. Available at http://www.aab-pts.org/Stats [accessed October 2009].
  4. Andersen AN, Goossens V, Gianaroli L, et al. Assisted reproductive technology in Europe, 2003. Results generated from European registers by ESHRE. Hum. Reprod. 2007;22:1513–1525
  5. Arce JC, Ziebe S, Lundin K, et al. Interobserver agreement and intraobserver reproducibility of embryo quality assessments. Hum. Reprod. 2006;21:2141–2148
  6. Bavister BD, Andrews JC. A rapid sperm motility bioassay procedure for quality-control testing of water and culture media. J. In Vitro Fert. Embryo Transfer. 1988;5:67–75
  7. Baxter AE, Mayer JF, Shipley SK, Catherino WH. Interobserver and intraobserver variation in day 3 embryo grading. Fertil. Steril. 2006;86:1608–1615
  8. Cai X, Pomeroy KO, Mattox JH. Application study of human sperm motility bioassay in IVF laboratory quality control. Zhonghua Nan Ke Xue. 2006;12:625–628
  9. Centro de Estudio e Investigación de la Fertilidad 2008. Available at http://www.ceifer.es/calidad/ [accessed 15 October 2009].
  10. Claassens OE, Wehr JB, Harrison KL. Optimizing sensitivity of the human sperm motility assay for embryo toxicity testing. Hum. Reprod. 2000;15:1586–1591
  11. Clarke RN, Griffin PM, Biggers JD. Screening of maternal sera using a mouse embryo culture assay is not predictive of human embryo development or IVF outcome. J. Assist. Reprod. Genet. 1995;12:20–25
  12. De Jonge CJ, Centola GC, Reed ML, et al. Human sperm survival assay as a bioassay for the assisted reproductive technologies laboratory. J. Androl. 2003;24:16–18
  13. De Placido G, Wilding M, Strina I, et al. High outcome predictability after IVF using a combined store for zygote and embryo morphology and growth rate. Hum. Reprod. 2002;17:2402–2409
  14. Desai NN, Goldstein J, Rowland DY, Goldfarb JM. Morphological evaluation of human embryos and derivation of an embryo quality scoring system specific for day 3 embryos: a preliminary study. Hum. Reprod. 2000;15:2190–2196
  15. Elder KT, Kastrop P. Control de calidad en laboratorios de fertilización in vitro. Reprod. Hum. 2003;3(1):13–20
  16. Fisch JD, Rodriguez H, Ross R, et al. The graduated embryo score (GES) predicts blastocyst formation and pregnancy rate from cleavage-stage embryos. Hum. Reprod. 2001;16:1970–1975
  17. Gardner DK, Reed L, Linck D, et al. Quality control in human in vitro fertilization. Sem. Reprod. Med. 2005;23:319–324
  18. Genschow E, Scholz G, Brown N, et al. Development of prediction models for three in vitro embryotoxicity tests in an ECVAM validation study. In Vitro Mol. Toxicol. 2000;13:51–66
  19. Genschow E, Spielmann H, Scholz G, et al. The ECVAM international validation study on in vitro embryotoxicity tests: results of the definitive phase and evaluation of prediction models. European Centre for the Validation of Alternative Methods. Altern. Lab. Anim. 2002;30:151–176
  20. Go KJ. Quality control: a framework for the ART laboratory. In:  Kal BA,  May JV,  De Jonge CI editor. Handbook of the Assisted Reproduction Laboratory. Boca Raton: CRC Press; 2000;p. 253–268
  21. Holte J, Berglund L, Milton K, et al. Construction of an evidence-based integrated morphology cleavage embryo score for implantation potential of embryos scored and transferred on day 2 after oocyte retrieval. Hum. Reprod. 2007;22:548–557
  22. Keck C, Fischer R, Baukloh V, Alper M. Quality management in reproductive medicine. In:  Gardner DK,  Weissman A,  Howles CM,  Shohan Z editor. Textbook of Assisted Reproductive Techniques. Laboratory and Clinical Perspectives. London and New York: Taylor and Francis; 2004;p. 477–494
  23. Kim JJ, Patton WC, Corselli J, et al. Mouse embryonic stem cells for quality control testing in assisted reproductive technology programs. J. Reprod. Med. 2005;50:533–538
  24. Lane M, Mitchell M, Cashman KS, et al. To QC or not to QC: the key to a consistent laboratory?. Reprod. Fertil. Dev. 2008;20:23–32
  25. Magli MC, Van den Abbeel E, Lundin K, et al. Revised guidelines for good practice in IVF laboratories. Hum. Reprod. 2008;23:1253–1262
  26. Matson PL. Internal and external quality assurance in the IVF laboratory. Hum. Reprod. 1998;13:156–165
  27. Parinaud JM, Reme JM, Monrozies X, et al. Mouse system quality control is necessary before the use of new material for in vitro fertilization and embryo transfer. J. In Vitro Fertil. Embryo Transfer. 1987;4:56–58
  28. The Practice Committee of the American Society for Reproductive Medicine and the Practice Committee of the Society for Assisted Reproductive Technology, 2006. Revised guidelines for human embryology and andrology laboratories. Fertil. Steril. 86 (Suppl. 4), 57–72.
  29. Quinn P. The development and impact of culture media for assisted reproductive technologies. Fertil. Steril. 2004;81:27–29
  30. Rinehart JS, Bavister BD, Gerrity M. Quality control in the in vitro fertilization laboratory: comparison of bioassay system for water quality. J. In Vitro Fertil. Embryo Transfer. 1988;5:335–342
  31. Scott LF, Sundaram SG, Smith S. The relevance and use of mouse embryo bioassays for quality control in an assisted reproductive technology program. Fertil. Steril. 1993;60:559–568
  32. Sharpe-Timms KL, Zimmer RL. Oocyte and pre-embryo classification. In:  Kal BA,  May JV,  De Jonge CI editor. Handbook of the Assisted Reproduction Laboratory. Boca Raton: CRC Press; 2000;p. 179–196
  33. Van den Bergh M, Baszó I, Biramane J, et al. Quality control in IVF with mouse bioassays: a four years’ experience. J. Assist. Reprod. Genet. 1996;13:733–738

 Jose Castilla graduated in medicine in 1985, completed his PhD in 1986 (Granada University) and then specialised in clinical analyses. He has been Director of the Andrology and Embryology, Virgen de las Nieves, Granada, Spain since 1991 and founded the CEIFER sperm bank in 1993. He has been co-ordinator of the Spanish External Quality Control Programme for Semen Analysis since 1999 and for the Assisted Reproduction Laboratory since 2003. A founder member of the Spanish Association of Clinical Embryologists (ASEBIR), and on its executive committee from 1993 to 2000, he is currently on the executive committee of the Spanish Fertility Society and deputy co-ordinator of ESHRE’s Special Interest Group in Andrology.

PII: S1472-6483(09)00148-5

doi: 10.1016/j.rbmo.2009.09.033

Reproductive BioMedicine Online
Volume 20, Issue 1 , Pages 68-74 , January 2010

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