GPR3 may not be a potential candidate gene for premature ovarian failure

Zhou, Sirui; Wang, Binbin; Ni, Feng; Wang, Jing; Cao, Yunxia; Ma, Xu

doi:10.1016/j.rbmo.2009.10.013

« Previous Next »Reproductive BioMedicine Online
Volume 20, Issue 1 , Pages 53-55, January 2010

GPR3 may not be a potential candidate gene for premature ovarian failure

Sirui Zhou
- Graduate School, Peking Union Medical College, Beijing 100730, China
- National Research Institute for Family Planning, Beijing 100081, China
- Binbin Wang and Sirui Zhou contributed equally to this work.
Binbin Wang
- Graduate School, Peking Union Medical College, Beijing 100730, China
- National Research Institute for Family Planning, Beijing 100081, China
- Binbin Wang and Sirui Zhou contributed equally to this work.
Feng Ni
- Reproductive Medicine Centre, The First Affiliated Hospital, Anhui Medical University, Hefei, China
Jing Wang
- Graduate School, Peking Union Medical College, Beijing 100730, China
- National Research Institute for Family Planning, Beijing 100081, China
Yunxia Cao
- Reproductive Medicine Centre, The First Affiliated Hospital, Anhui Medical University, Hefei, China
- Corresponding authors.
Xu Ma
- Graduate School, Peking Union Medical College, Beijing 100730, China
- National Research Institute for Family Planning, Beijing 100081, China
- World Health Organization Collaborating Centre for Research in Human Reproduction, Beijing, China
- Corresponding authors.

Received 26 March 2009; received in revised form 9 June 2009; accepted 13 October 2009. published online 07 December 2009.

Declaration: The authors report no financial or commercial conflicts of interest.

Abstract

The G protein-coupled receptor gene GPR3 is expressed predominantly in oocytes, and functions in the early development of oocytes in the ovarian follicle. GPR3 is essential for meiotic arrest maintenance in mice, which makes it a candidate gene for premature ovarian failure (POF). The coding region of GPR3 was screened in 100 Chinese POF patients for variants of the GPR3 gene. Except for one novel variant in the 3′UTR region in three subjects and another novel synonymous c.135G→A variant in one subject, no perturbations were found in the coding region. The results of this study suggested that mutations in GPR3 are not a common cause of POF in Chinese women.

Keywords: G protein-coupled receptor 3, premature ovarian failure, sequence variant, sequencing

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Professor Yunxia Cao obtained her MD degree in 1985, her MSc degree in 1988 and her PhD in 2000. In 1998, she established the Reproductive Medical Center in Anhui Province, China, and produced the first IVM baby and first baby derived from frozen-thawed oocytes in Anhui Province, China. Professor Yunxia Cao is a well-known infertility specialist in China, and she is a National Board Member for Reproductive Medicine. Professor Cao research interests include the mechanisms underlying polycystic ovary syndrome, fertility preservation for women and the simplification of IVF treatment.