Reproductive BioMedicine Online
Volume 20, Issue 1 , Pages 53-55 , January 2010

GPR3 may not be a potential candidate gene for premature ovarian failure

  • Sirui Zhou

      Affiliations

    • Graduate School, Peking Union Medical College, Beijing 100730, China
    • National Research Institute for Family Planning, Beijing 100081, China
    • Binbin Wang and Sirui Zhou contributed equally to this work.
    • ,
  • Binbin Wang

      Affiliations

    • Graduate School, Peking Union Medical College, Beijing 100730, China
    • National Research Institute for Family Planning, Beijing 100081, China
    • Binbin Wang and Sirui Zhou contributed equally to this work.
    • ,
  • Feng Ni

      Affiliations

    • Reproductive Medicine Centre, The First Affiliated Hospital, Anhui Medical University, Hefei, China
    • ,
  • Jing Wang

      Affiliations

    • Graduate School, Peking Union Medical College, Beijing 100730, China
    • National Research Institute for Family Planning, Beijing 100081, China
    • ,
  • Yunxia Cao

      Affiliations

    • Reproductive Medicine Centre, The First Affiliated Hospital, Anhui Medical University, Hefei, China
    • Corresponding Author InformationCorresponding authors.
    • ,
  • Xu Ma

      Affiliations

    • Graduate School, Peking Union Medical College, Beijing 100730, China
    • National Research Institute for Family Planning, Beijing 100081, China
    • World Health Organization Collaborating Centre for Research in Human Reproduction, Beijing, China
    • Corresponding Author InformationCorresponding authors.

Received 26 March 2009 ,Revised 9 June 2009 ,Accepted 13 October 2009.

References 

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  2. Burton KA, Van Ee CC, Purcell K, et al. Autosomal translocation associated with premature ovarian failure. J. Med. Genet. 2000;37:E2
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  4. Freudzon L, Norris RP, Hand AR, et al. Regulation of meiotic prophase arrest in mouse oocytes by GPR3, a constitutive activator of the Gs G protein. J. Cell Biol. 2005;171:255–265
  5. Harris SE, Chand AL, Winship IM, et al. Identification of novel mutations in FOXL2 associated with premature ovarian failure. Mol. Human Reprod. 2002;8:729–733
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  9. Marozzi A, Manfredini E, Tibiletti MG, et al. Molecular definition of Xq common-deleted region in patients affected by premature ovarian failure. Hum. Genet. 2000;107:304–311
  10. Mehlmann LM. Oocyte-specific expression of Gpr3 is required for the maintenance of meiotic arrest in mouse oocytes. Dev. Biol. 2005;288:397–404
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  12. Norris RP, Freudzon L, Freudzon M, et al. A Gs-linked receptor maintains meiotic arrest in mouse oocytes, but luteinizing hormone does not cause meiotic resumption by terminating receptor-Gs signaling. Dev. Biol. 2007;310:240–249
  13. Qin Y, Choi Y, Zhao H, et al. NOBOX homeobox mutation causes premature ovarian failure. Am. J. Hum. Genet. 2007;81:576–581
  14. Saeki Y, Ueno S, Mizuno R, et al. Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system. FEBS Lett. 1993;336:317–322
  15. Simpson JL. Genetic and phenotypic heterogeneity in ovarian failure: overview of selected candidate genes. Ann. N.Y. Acad. Sci. 2008;1135:146–154
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  17. Suzumori N, Pangas SA, Rajkovic A. Candidate genes for premature ovarian failure. Curr. Med. Chem. 2007;14:353–357
  18. Tanaka S, Ishii K, Kasai K, et al. Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth. J. Biol. Chem. 2007;282:10506–10515
  19. Uhlenbrock K, Gassenhuber H, Kostenis E. Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. Cell Signal. 2002;14:941–953

 Professor Yunxia Cao obtained her MD degree in 1985, her MSc degree in 1988 and her PhD in 2000. In 1998, she established the Reproductive Medical Center in Anhui Province, China, and produced the first IVM baby and first baby derived from frozen-thawed oocytes in Anhui Province, China. Professor Yunxia Cao is a well-known infertility specialist in China, and she is a National Board Member for Reproductive Medicine. Professor Cao research interests include the mechanisms underlying polycystic ovary syndrome, fertility preservation for women and the simplification of IVF treatment.

PII: S1472-6483(09)00156-4

doi: 10.1016/j.rbmo.2009.10.013

Reproductive BioMedicine Online
Volume 20, Issue 1 , Pages 53-55 , January 2010

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