Reproductive BioMedicine Online
Volume 20, Issue 1 , Pages 48-52 , January 2010

Ovarian function 6years after cryopreservation and transplantation of whole sheep ovaries

  • A. Arav

      Affiliations

    • Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
    • A Arav and Z Gavish contributed equally to this work.
    • Corresponding Author InformationCorresponding author.
    • ,
  • Z. Gavish

      Affiliations

    • Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
    • A Arav and Z Gavish contributed equally to this work.
    • ,
  • A. Elami

      Affiliations

    • Department of Cardiovascular Surgery, Hadassah University Hospital, Jerusalem, Israel
    • ,
  • Y. Natan

      Affiliations

    • Core Dynamics, Ness Ziona, Israel
    • ,
  • A. Revel

      Affiliations

    • Department of Obstetrics and Gynecology, Hadassah University Hospital, Jerusalem, Israel
    • ,
  • S. Silber

      Affiliations

    • Infertility Center of St. Louis, St. Luke’s Hospital, St. Louis, MO, USA
    • ,
  • R.G. Gosden

      Affiliations

    • CRMI Weill Medical College of Cornell University, New York, NY 10021, USA
    • ,
  • P. Patrizio

      Affiliations

    • Yale University Fertility Center, New Haven, CT, USA

Received 30 March 2009 ,Revised 21 May 2009 ,Accepted 16 October 2009.

References 

  1. Arav A, Revel A, Nathan Y, et al. Oocyte recovery, embryo development and ovarian function after cryopreservation and transplantation of whole sheep ovary. Hum. Reprod. 2005;20:3554–3559
  2. Armitage WJ. Cryopreservation of animal cells. Symp. Soc. Exp. Biol. 1987;41:379–393
  3. Baird DT, Webb R, Campbell BK, et al. Long-term ovarian function in sheep after ovariectomy and transplantation of autografts stored at −196°C. Endocrinology. 1999;140:462–471
  4. Balasubramanian SK, Coger RN. Heat and mass transfer during the cryopreservation of a bioartificial liver device: a computational model. ASAIO J. 2005;51:184–193
  5. Baudot A, Courbiere B, Odagescu V, et al. Towards whole sheep ovary cryopreservation. Cryobiology. 2007;55:236–248
  6. Chen CH, Chen SG, Wu GJ, et al. Autologous heterotopic transplantation of intact rabbit ovary after frozen banking at −196 degrees C. Fertil. Steril. 2006;86(suppl. 4):1059–1066
  7. Courbiere B, Massardier J, Salle B, et al. Follicular viability and histological assessment after cryopreservation of whole sheep ovaries with vascular pedicle by vitrification. Fertil. Steril. 2005;84(suppl. 2):1065–1071
  8. de Souza CJ, Campbell BK, Baird DT. Incipient ovarian failure associated with raised levels of follicle stimulating hormone and reduced levels of inhibin A in older sheep. Hum. Reprod. 1998;13:3016–3022
  9. Elami A, Gavish Z, Korach A, et al. Successful restoration of function of frozen/thawed isolated rat hearts. J. Thorac. Cardiovasc. Surg. 2008;135:666–672 e1
  10. Fahy GM, MacFarlane DR, Angell CA, Meryman HT. Vitrification as an approach to cryopreservation. Cryobiology. 1984;21:407–426
  11. Gavish Z, Ben-Haim M, Arav A. Cryopreservation of whole murine and porcine livers. Rejuvenation Res. 2008;11:765–772
  12. Imhof M, Bergmeister H, Lipovac M, et al. Orthotopic microvascular reanastomosis of whole cryopreserved ovine ovaries resulting in pregnancy and live birth. Fertil. Steril. 2006;85(suppl. 1):1208–1215
  13. Ishijima T, Kobayashi Y, Lee DS, et al. Cryopreservation of canine ovaries by vitrification. J. Reprod. Dev. 2006;52:293–299
  14. Karlsson JO, Toner M. Long-term storage of tissues by cryopreservation: critical issues. Biomaterials. 1996;17:243–256
  15. Lee SJ, Schover LR, Partridge AH, et al. Recommendations on fertility preservation in cancer patients. J. Clin. Oncol. 2006;24:2917–2931
  16. Liu J, Van der Elst J, Van den Broecke R, Dhont M. Early massive follicle loss and apoptosis in heterotopically grafted newborn mouse ovaries. Hum. Reprod. 2002;17:605–611
  17. Martinez-Madrid B, Camboni A, Dolmans MM, et al. Apoptosis and ultrastructural assessment after cryopreservation of whole human ovaries with their vascular pedicle. Fertil. Steril. 2007;87:1153–1165
  18. Meirow D. Reproduction post-chemotherapy in young cancer patients. Mol. Cell. Endocrinol. 2000;169:123–131
  19. Norman S, Rzepakosky V, Brosh T, Salai M. Maintaining viability of osteochondral allografts for transplantation using directional freezing. J. Bone Joint Surg. Br. 2006;88-B(suppl. 2):344
  20. O’Brien JK, Robeck TR. Development of sperm sexing and associated assisted reproductive technology for sex preselection of captive bottlenose dolphins (Tursiops truncatus). Reprod. Fertil. Dev. 2006;18:319–329
  21. Revel A, Elami A, Bor A, et al. Whole sheep ovary cryopreservation and transplantation. Fertil. Steril. 2004;82:1714–1715
  22. Salle B, Demirci B, Franck M, et al. Long-term follow-up of cryopreserved hemi-ovary autografts in ewes: pregnancies, births, and histologic assessment. Fertil. Steril. 2003;80:172–177
  23. Saragusty J, Gacitua H, Pettit MT, Arav A. Directional freezing of equine semen in large volumes. Reprod. Domest. Anim. 2007;42:610–615
  24. Silber S, Pineda J, DeRosa M, et al. Successful pregnancy after whole ovary microvascular transplantation. Fertil. Steril. 2008;90(suppl. 1):S37–S38
  25. Silber SJ, DeRosa M, Pineda J, et al. A series of monozygotic twins discordant for ovarian failure: ovary transplantation (cortical versus microvascular) and cryopreservation. Hum. Reprod. 2008;23:1531–1537
  26. Wallace WH, Anderson RA, Irvine DS. Fertility preservation for young patients with cancer: who is at risk and what can be offered. Lancet Oncol. 2005;6:209–218
  27. Yin H, Wang X, Kim SS, et al. Transplantation of intact rat gonads using vascular anastomosis: effects of cryopreservation, ischaemia and genotype. Hum. Reprod. 2003;18:1165–1172
  28. Zeron Y, Ocheretny A, Kedar O, Borochov A, Sklan D. Arav A. Seasonal changes in bovine fertility: relation to oocyte and granulosa membrane properties folicular fluid. Reproduction. 2001;121:447–454

 Dr Arav received his bachelor degree at the Hebrew University of Jerusalem, his veterinary degree at the University of Bologna, Italy, and his PhD in the area of cryobiology and thermodynamics via a joint program between the University of California, Berkeley and the University of Bologna. He completed his post-doctoral studies at UC Davis and holds a position at the Volcani Center as senior scientist in the field of cryobiology and reproduction. Dr Arav established IMT Ltd, Israel and has developed various issued patents. He has published over 100 papers and book chapters and received many awards.

PII: S1472-6483(09)00162-X

doi: 10.1016/j.rbmo.2009.10.019

Reproductive BioMedicine Online
Volume 20, Issue 1 , Pages 48-52 , January 2010

Article Tools

* Image Usage & Resolution