Reproductive BioMedicine Online
Volume 20, Issue 2 , Pages 171-174 , February 2010

Time to re-think: ovarian tissue transplantation versus whole ovary transplantation

Received 4 June 2009 ,Revised 13 July 2009 ,Accepted 11 November 2009.

References 

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  2. Bedaiwy MA, Jeremias E, Gurunluoglu R, et al. Restoration of ovarian function after autotransplantation of intact frozen–thawed sheep ovaries with microvascular anastomosis. Fertil. Steril. 2003;79:594–602
  3. Courbiere B, Caquant L, Mazoyer C, et al. Difficulties improving ovarian functional recovery by microvascular transplantation and whole ovary vitrification. Fertil. Steril. 2009;91:2697–2706
  4. Demeestere I, Simon P, Emiliani S, et al. Fertility preservation: successful transplantation of cryopreserved ovarian tissue in a young patient previously treated for Hodgkin’s disease. Oncologist. 2007;12:1437–1442
  5. Donnez J, Dolmans MM, Demylle D, et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004;364:1405–1410
  6. Grazul-Bilska AT, Banerjee J, Yazici I, et al. Morphology and function of cryopreserved whole ovine ovaries after heterotopic autotransplantation. Reprod. Biol. Endocrinol. 2008;6:16
  7. Imhof M, Bergmeister H, Lipovac M, et al. Orthotopic microvascular reanastomosis of whole cryopreserved ovine ovaries resulting in pregnancy and live birth. Fertil. Steril. 2006;85(Suppl. 1):1208–1215
  8. Kim SS. Fertility preservation in female cancer patients: current developments and future directions. Fertil. Steril. 2006;85:1–11
  9. Kim SS, Lee WS, Chung MK, et al. Long-term ovarian function and fertility after heterotopic autotransplantation of cryobanked human ovarian tissue: 8-year experience in cancer patients. Fertil. Steril. 2009;91:2349–2354
  10. Kim SS, Radford J, Harris M, et al. Ovarian tissue harvested from lymphoma patients to preserve fertility may be safe for autotransplantation. Hum. Reprod. 2001;16:2056–2060
  11. Kim SS, Yang HW, Kang HG, et al. Quantitative assessment of ischemic tissue damage in ovarian cortical tissue with or without antioxidant (ascorbic acid) treatment. Fertil. Steril. 2004;82:679–685
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  13. Leporrier M, von Theobald P, Roffe JL, Muller G. A new technique to protect ovarian function before pelvic irradiation. Heterotopic ovarian autotransplantation. Cancer. 1987;60:2201–2204
  14. Meirow D, Hardan I, Dor J, et al. Searching for evidence of disease and malignant cell contamination in ovarian tissue stored from hematologic cancer patients. Hum. Reprod. 2008;23:1007–1013
  15. Meirow D, Levron J, Eldar-Geva T, et al. Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy. N. Engl. J. Med. 2005;353:318–321
  16. Mhatre P, Mhatre J. Orthotopic ovarian transplant – review and three surgical techniques. Pediatr. Transplant. 2006;10:782–787
  17. Morris R. The ovarian graft. NY Med. J. 1895;62:436
  18. Onions VJ, Mitchell MR, Campbell BK, Webb R. Ovarian tissue viability following whole ovine ovary cryopreservation: assessing the effects of sphingosine-1-phosphate inclusion. Hum. Reprod. 2008;23:606–618
  19. Pegg DE. The role of vitrification techniques of cryopreservation in reproductive medicine. Hum. Fertil. (Camb.). 2005;8:231–239
  20. Piver P, Amiot C, Agnani G, et al. Two Pregnancies obtained after a new technique of autotransplantation of cryopreserved ovarian tissue. Hum. Reprod. 2009;24:i15;O-35
  21. Silber SJ, Grudzinskas G, Gosden RG. Successful pregnancy after microsurgical transplantation of an intact ovary. N. Engl. J. Med. 2008;359:2617–2618
  22. Yin H, Wang X, Kim SS, et al. Transplantation of intact rat gonads using vascular anastomosis: effects of cryopreservation, ischaemia and genotype. Hum. Reprod. 2003;18:1165–1172

 S Samuel Kim is a specialist in reproductive endocrinology and infertility. He is also a highly-esteemed scientist whose reputation as a pioneer in ovarian tissue cryopreservation and transplantation has been recognized worldwide. Currently, Dr Kim is the Head and Associate Professor of the Division of Reproductive Endocrinology at the University of Kansas, School of Medicine. He is also the Director for the Fertility Preservation Program at the University of Kansas Cancer Center

PII: S1472-6483(09)00232-6

doi: 10.1016/j.rbmo.2009.11.019

Reproductive BioMedicine Online
Volume 20, Issue 2 , Pages 171-174 , February 2010

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