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Volume 20, Issue 3, Pages 335-340 (March 2010)


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Contribution of in-vitro maturation in ovarian stimulation cycles of poor-responder patients

Daniela Paes de Almeida Ferreira Bragaab, Rita de Cássia Sávio Figueiraa, Renata Cristina Ferreiraa, Fabio Firmbach Pasqualottoc, Assumpto Iaconelli Jra, Edson Borges JrabCorresponding Author Informationemail address

Received 12 March 2009; received in revised form 18 June 2009; accepted 26 November 2009. published online 01 February 2010.

Abstract 

This cohort study evaluated whether rescue spontaneous maturation (RSM) could be a valid method to increase the number of embryos available for transfer and whether transfers with RSM-derived embryos would contribute to clinical outcomes of poor-responder patients in ovarian stimulation cycles. The study included 440 patients undergoing intracytoplasmic sperm injection cycles in which fewer than five metaphase II (MII) oocytes and at least one immature oocyte were retrieved after follicle aspiration. Patients were allocated into two groups based on the injected oocytes’ nuclear maturation status: MII group (n=330), in which only embryos derived from MII oocytes were transferred, and RSM group (n=110), in which at least one embryo derived from an RSM oocyte was transferred. No differences between the MII and RSM groups were observed for pregnancy (16.7% versus 16.5%) or miscarriage (25.5% versus 29.4%) rates, respectively. The RSM group had a higher number of transferred embryos (1.87±1.24 versus 2.35±1.22; P<0.001), a lower embryo transfer cancellation rate (14.5% versus 6.36%; P=0.025) and lower implantation rate (15.4±31.5% versus 10.5±22.3%; not significant). These findings suggest that RSM did not contribute to the outcomes in poor-responder cycles.

Declaration: The authors report no financial or commercial conflicts of interest.

a Fertility – Assisted Fertilization Center, Av. Brigadeiro Luis Antônio, 4545, São Paulo 01402-001, Brazil

b Sapientiae Institute, Rua. Vieira Maciel, 62, São Paulo 04503-040, Brazil

c Institute of Biotechnology, University of Caxias do Sul, Rua Pinheiro Machado, 2569 Room 23/24, Caxias do Sul, Rio Grande do Sul 95020-172, Brazil

Corresponding Author InformationCorresponding author.

 Edson Borges Jr obtained his MD degree in 1984 at the University of Campinas, his first PhD in urology in 2005 at the Federal University of São Paulo and his second PhD in gynaecology in 2007 at the Botucatu Medical School in São Paulo State University. At present he is the founder partner and Managing Director of Fertility – Assisted Fertilization Center in São Paulo, Brazil and Scientific Director at Sapientiae Institute in São Paulo, Brazil.

PII: S1472-6483(09)00286-7

doi:10.1016/j.rbmo.2009.12.009


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