Reproductive BioMedicine Online
Volume 20, Issue 4 , Pages 485-491 , April 2010

Effects of race/ethnicity on triple CGG counts in the FMR1 gene in infertile women and egg donors

  • Norbert Gleicher

      Affiliations

    • The Center for Human Reproduction (CHR), 21 East 69th Street, New York, NY 10021, USA
    • Foundation for Reproductive Medicine, New York, NY, USA
    • Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    • Corresponding Author InformationCorresponding author.
    • ,
  • Andrea Weghofer

      Affiliations

    • The Center for Human Reproduction (CHR), 21 East 69th Street, New York, NY 10021, USA
    • Department of Obstetrics and Gynecology, Vienna University School of Medicine, Vienna, Austria
    • ,
  • David H. Barad

      Affiliations

    • The Center for Human Reproduction (CHR), 21 East 69th Street, New York, NY 10021, USA
    • Foundation for Reproductive Medicine, New York, NY, USA
    • Departments of Epidemiology and Social Medicine and Obstetrics, Gynecology and Women’s Health, Albert Einstein College of Medicine, Bronx, NY, USA

Received 17 August 2009 ,Revised 2 September 2009 ,Accepted 30 November 2009.

References 

  1. Allen EG, Sullivan AK, Marcus M, et al. Examination of reproductive aging milestones among women who carry the FMR1 premutation. Hum. Reprod. 2007;22:2142–2152
  2. Bächner D, Manca A, Steinbach P, et al. Enhanced expression of the murine FMR1 gene during germ cell proliferation suggests a special function in both the male and female gonad. Hum. Mol. Genet. 1993;2:2043–2050
  3. Barad DH, Weghofer A, Gleicher N. Age-specific levels for basal follicle stimulating hormone assessment of ovarian function. Obstet. Gynecol. 2007;109:1404–1410
  4. Bodega B, Bione S, Dalpra L, et al. Influence of intermediate and uninterrupted FMR1 CGG expansions in premature ovarian failure manifestation. Hum. Reprod. 2006;21:952–957
  5. Chen LS, Tassone F, Sahota P, Hagermann PJ. The (CGG)n repeat element within the 5′untranslated region of the FMR1 message provides both positive and negative cis effects on in vivo translation of a downstream reporter. Hum. Mol. Genet. 2003;12:3067–3074
  6. Crawford DC, Acuna JM, Sherman SL. FMR1 and the fragile X syndrome: human genome epidemiology review. Genet. Med. 2001;3:359–371
  7. Crawford DC, Meadows KL, Newman JL, et al. Prevalence of the fragile X syndrome in African Americans. Am. J. Med. Genet. 2002;3:359–371
  8. Fragile X-Primary Ovarian Insufficiency (FX-POI) Working Group, 2008. Available from: <http://www.nichd.nih.gov/publications/pubs/upload/NIH_Research_Plan_on_Fragile_X_and_Assoc_Disorders-06-2009.pdf> (accessed 29/10/09).
  9. Fu YH, Kuhl DP, Pizzuti A, et al. Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox. Cell. 1991;67:1047–1058
  10. Gleicher N, Weghofer A, Barad DH. A pilot study of premature ovarian senescence. I. Correlation of triple CGG repeats on the FMR1 gene to ovarian reserve parameters FSH and anti-Müllerian hormone. Fertil. Steril. 2009;91:1700–1706
  11. Gleicher N, Weghofer A, Barad DH. A pilot study of premature ovarian senescence. II. Different genotype and phenotype for genetic and autoimmune etiologies. Fertil. Steril. 2009;91:1707–1711
  12. Gleicher N, Weghofer A, Li JM, Barad D. Differences in ovarian function parameters between Chinese and Caucasian oocyte donors: do they offer an explanation for lower IVF pregnancy rates in Chinese women?. Hum. Reprod. 2007;22:2879–2882
  13. Gleicher N, Weghofer A, Oktay K, Barad DH. The number of triple CGG repeats on the FMR1 gene: a new test reflective of diminished ovarian reserve and female infertility. Hum. Reprod. 2008;23:i204–i205
  14. Gleicher N, Weghofer A, Oktay K, Barad D. Relevance of low triple CGG repeats on the FMR1 gene to ovarian reserve. RBMOnline. 2009;19:385–390
  15. Greenseid K, Merhi Z, Jindal S, Lieman H, Santoro N, Pal L. Race and infertility diagnosis predict clinical pregnancy among IVF patients with elevated FSH levels. Fertil. Steril. 2004;82(Suppl.):28s
  16. Hundscheid RDL, Braat DDM, Kiemaney LALM, Smits APT, Thomas CMG. Increased serum FSH in female fragile X premutation carriers with either regular menstrual cycles or on oral contraceptives. Hum. Reprod. 2001;16:457–462
  17. Luborsky JL, Meyer P, Sowers MF, Gold EB, Santoro N. Premature menopause in a multi-ethnic population study of the menopause transition. Hum. Reprod. 2003;18:199–206
  18. Montgomery Rice V, Ata A, Archibone AE, Demers LM, Legro R, Coney P. Increased end organ sensitivity of estrogen in Black women. Fertil. Steril. 2006;86:S325–S326
  19. Murray A, Ennis S, MacSwiney F, Webb J, Morton NE. Reproductive and menstrual history of females with fragile X expansions. Eur. J. Hum. Genet. 2000;8:247–252
  20. Pluzhnikov A, Nolan DK, Tan Z, McPeek MS, Ober C. Correlation of intergenerational family sizes suggests a genetic component of reproductive fitness. Am. J. Hum. Genet. 2007;81:165–169
  21. Purcell K, Schembri M, Frazier LM, Rall MJ, Shen S, Croughan M, et al. Asian ethnicity is associated with reduced pregnancy outcomes after assisted reproductive technology. Fertil. Steril. 2007;87:297–302
  22. Rifé M, Nadal A, Mila M, Willemsen R. Immunohistochemical FMRP studies in full mutated female fetus. Am. J. Med. Genet. 2004;124A:129–132
  23. Tukey J. Exploratory data analysis. In: Addison-Wesley Series in Behavioral Science: Quantitative Methods. Reading, MA: Addison-Wesley; 1977;
  24. Welt CK, Smith PC, Taylor AE. Evidence of early ovaria aging in fragile X premutation carriers. J. Clin. Endocrinol. Metab. 2004;89:4569–4574
  25. Wittenberger MD, Hagerman RJ, Sherman SL, et al. The FMR1 premutation and reproduction. Fertil. Steril. 2007;87:456–465

 A graduate of Tel Aviv University School of Medicine, Israel, Norbert Gleicher, MD, FACOF, FACS, completed residency and fellowship at Mount Sinai Medical Center in New York, where he joined the faculty as Assistant Professor and Division Head. He then was recruited in 1981 as Department Chair at Mount Sinai Hospital and Professor at Rush Medical College in Chicago, where he founded The Center for Human Reproduction (CHR), initially in Chicago and later in New York City. He currently serves as Medical Director of CHR-NY and is a Visiting Professor at Yale University School of Medicine. Dr Gleicher has published hundreds of peer-reviewed papers, has edited a number of major text books, served as Editor-in-Chief for the American Journal of Reproductive Immunology and the Journal of Assisted Reproduction and Genetics and on the editorial boards of many other publications.

PII: S1472-6483(09)00301-0

doi: 10.1016/j.rbmo.2009.12.017

Reproductive BioMedicine Online
Volume 20, Issue 4 , Pages 485-491 , April 2010

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