LH concentrations do not correlate with pregnancy in rFSH/GnRH antagonist cycles
Received 2 July 2009; received in revised form 21 September 2009; accepted 30 November 2009. published online 04 February 2010.
Abstract
The possible relationship between endogenous LH concentrations and clinical outcome was evaluated in 750 patients treated with a standardized gonadotrophin-releasing hormone (GnRH) antagonist and recombinant FSH (rFSH)-only protocol. Serum LH concentrations were measured during stimulation by a central laboratory and patients were stratified into quantiles of <P25, P25–P75, and >P75. The P25 values were 3.38IU/l, 0.93IU/l, and 0.91IU/l on stimulation days 1, 5, and 8, respectively. The ongoing pregnancy rates per started cycle of patients within the <P25 subset on stimulation day 1, 5, or 8 were highly similar to those in the P25–P75, and >P75 subsets and ranged in the various subsets between 35.0% and 39.5%. In keeping with previous, smaller studies, these findings demonstrate that in good prognosis, non-obese patients endogenous LH in a GnRH antagonist protocol is able to support treatment with rFSH only.
Declaration: The authors report no financial or commercial conflicts of interest.
aCenter for Assisted Reproduction, Bedford, Texas, USA
bCenter for Reproductive Medicine, Universitair Ziekenhuis Brussel, Belgium
cGlobal Medical Affairs, Schering-Plough Kenilworth, NJ, USA
dSchering-Plough Research Institute, Oss, The Netherlands
Corresponding author.
Kevin Doody, MD, received his medical degree and served a residency in Obstetrics and Gynecology at Baylor College of Medicine in Houston. After completing his residency, Dr Doody received subspecialty training at UT Southwestern Medical Center. He completed his fellowship in Reproductive Endocrinology/Infertility in 1989. He is board certified in Obstetrics and Gynecology and subspecialty board certified in Reproductive Endocrinology/Infertility. Dr Doody has been repeatedly honored as one of Fort Worth’s Top Docs, one of Texas’ Super Doctors and one of the Best Doctors in America. Dr Doody was also recognized as Microsoft Physician of the Year 2004.
ABSTRACT
Kevin Doody, MD, received his medical degree and served a residency in Obstetrics and Gynecology at Baylor College of Medicine in Houston. After completing his residency, Dr Doody received subspecialty training at UT Southwestern Medical Center. He completed his fellowship in Reproductive Endocrinology/Infertility in 1989. He is board certified in Obstetrics and Gynecology and subspecialty board certified in Reproductive Endocrinology/Infertility. Dr Doody has been repeatedly honored as one of Fort Worth’s Top Docs, one of Texas’ Super Doctors and one of the Best Doctors in America. Dr Doody was also recognized as Microsoft Physician of the Year 2004.