Reproductive BioMedicine Online
Volume 20, Issue 4 , Pages 559-564 , April 2010

Complete globozoospermia associated with PLCζ deficiency treated with calcium ionophore and ICSI results in pregnancy

  • S.L. Taylor

      Affiliations

    • The Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, VA, USA
    • ,
  • S.Y. Yoon

      Affiliations

    • Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA
    • ,
  • M.S. Morshedi

      Affiliations

    • The Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, VA, USA
    • ,
  • D.R. Lacey

      Affiliations

    • The Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, VA, USA
    • ,
  • T. Jellerette

      Affiliations

    • Wesson’s Women and Infants’ Unit, Baystate Medical Center, Springfield, MA, USA
    • ,
  • R.A. Fissore

      Affiliations

    • Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA
    • ,
  • S. Oehninger

      Affiliations

    • The Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, VA, USA
    • Corresponding Author InformationCorresponding author.

Received 31 July 2009 ,Revised 19 August 2009 ,Accepted 2 December 2009.

References 

  1. Arslan M, Bocca S, Mirkin S, Barroso G, Stadtmauer L, Oehninger S. Controlled ovarian hyperstimulation protocols for in vitro fertilization: two decades of experience after the birth of Elizabeth Carr. Fertil. Steril. 2005;84:555–569
  2. Carbone DJ, McMahon JT, Levin HS, Thomas AJ, Agarwal A. Role of electron microscopy of sperm in the evaluation of male infertility during the era of assisted reproduction. Urology. 1998;52:301–305
  3. Dam AHDM, Koscinski I, Kremer JAM, et al. Homozygous mutation in SPATA 16 is associated with male infertility in human globozoospermia. Am. J. Hum. Genet. 2007;81:813–820
  4. Dirican EK, Isik A, Vicdan K, Sozen E, Suludere Z. Clinical pregnancies and livebirths achieved by intracytoplasmic injection of round headed acrosomeless spermatozoa with and without oocyte activation in familial globozoospermia: case report. Asian J. Androl. 2008;10:332–336
  5. Holstein AF, Schirren CG, Schirren C, Mauss J. Round headed spermatozoa: a cause of male infertility. Dtsch. Med. Wochenschr. 1973;98:61–62
  6. Larson KL, Brannian JD, Singh NP, et al. Chromatin structure in globozoospermia: a case report. J. Androl. 2001;22:424–431
  7. Liu J, Nagy Z, Joris H, Tournaye H, Devroey P, Van Steirteghem A. Successful fertilization and establishment of pregnancies after intracytoplasmic sperm injection in patients with globozoospermia. Hum. Reprod. 1995;10:626–629
  8. Menkveld R, Stander FS, Kotze TJ, Kruger TF, van Zyl JA. The evaluation of morphological characteristics of human spermatozoa according to stricter criteria. Hum. Reprod. 1990;5:586–592
  9. Meyhöfer W. Beitrag zur cytophotometrischen beutreilung pathologisch verländerter samenzellen unter besonderer berücksichtiging der reunspermatozoen nach Feulgen-end fast greenfarbung. [Contribution to the cytophotometric evaluation of pathologically changed spermatozoa with special reference to round-shaped spermatozoa following Feuglen and fast green staining]. Zeitschrift für Haut- und Geschlechtskrankheiten. 1965;39:174–182
  10. Oehninger S, Acosta R, Morshedi M, Philput C, Swanson RJ, Acosta AA. Relationship between morphology and motion characteristics of human spermatozoa in semen and in the swim-up sperm fractions. J. Androl. 1990;11:446–452
  11. Pfeffer J, Pang MG, Hoegerman SF, et al. Aneuploidy frequencies in semen fractions from ten oligoasthenoteratozoospermic patients donating sperm for intracytoplasmic sperm injection. Fertil. Steril. 1999;72:472–478
  12. Riggs R, Mayer J, Dowling-Lacey D, Chi TF, Jones E, Oehninger S. Does storage time influence postthaw survival and pregnancy outcome? An analysis of 11,768 cryopreserved human embryos. Fertil. Steril. 2008;(Epub ahead of print)
  13. Schirren CG, Holstein AF, Schirren C. Uber die Morphologenese Rundkopfiger Spermatozoen des Menschen. Andrologie. 1971;3:117–125
  14. Sutovsky P, Neuber E, Schatten G. Ubiquitin-dependent sperm quality control mechanism recognizes spermatozoa with DNA defects as revealed by dual ubiquitin–TUNEL assay. Mol. Reprod. Dev. 2002;61:406–413
  15. Tejera A, Mollá M, Muriel L, Remohí J, Pellicer A, De Pablo JL. Successful pregnancy and childbirth after intracytoplasmic sperm injection with calcium ionophore oocyte activation in a globozoospermic patient. Fertil. Steril. 2008;90:1202
  16. Vicari E, Perdichizzi A, De Palma A, Burrello N, D’Agata R, Calogero AE. Globozoospermia is associated with chromatin structure abnormalities: case report. Hum. Reprod. 2002;17:2128–2133
  17. Weng SL, Taylor SL, Morshedi M, et al. Caspase activity and apoptotic markers in ejaculated human sperm. Mol. Hum. Reprod. 2002;8:984–991
  18. World Health Organization. WHO manual for the examination of semen and sperm/cervical mucus interaction. Cambridge, UK: Cambridge University Press; 1999;
  19. Yoon SY, Jellerette T, Salicioni AM, et al. Human sperm devoid of PLC, zeta 1 fail to induce Ca(2+) release and are unable to initiate the first step of embryo development. J. Clin. Invest. 2008;118:3671–3681

 Steven Taylor has been associated with the Andrology Laboratory of the Jones Institute for Reproductive Medicine for the past 10years. He earned his PhD in biomedical sciences from Old Dominion University in Norfolk, Virginia in 2002. He has served as an ad hoc reviewer for several scientific publications and has either authored or co-authored eighteen manuscripts in peer-reviewed journals. Current interests include medical laboratory science and most aspects of reproductive sciences including male reproductive biology, sperm biology, sperm DNA fragmentation and its effects on subsequent embryo development and reproductive endocrinology.

PII: S1472-6483(09)00337-X

doi: 10.1016/j.rbmo.2009.12.024

Reproductive BioMedicine Online
Volume 20, Issue 4 , Pages 559-564 , April 2010

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