Reproductive BioMedicine Online
Volume 20, Issue 4 , Pages 543-546, April 2010

Prospective randomized study for hydrotubation versus no hydrotubation before intrauterine insemination in unexplained infertility

Faculty of Medicine, Cairo University, Cairo, Egypt and The Egyptian IVF Center, Maadi, Cairo, Egypt

Received 6 July 2009; received in revised form 17 September 2009; accepted 8 December 2009. published online 03 February 2010.

Declaration: The authors report no financial or commercial conflicts of interest.

Abstract 

The purpose of the study was to investigate the value of hydrotubation before intrauterine insemination (IUI). In 228 patients with the diagnosis of unexplained infertility, ovarian stimulation was performed before IUI, using 100mg of clomiphine citrate for 5days from day 3 of the cycle and one ampoule of human menopausal gonadotrophin for 5days from day 6 of the cycle. Folliculometry and determination of LH concentration in urine were performed daily until LH became positive, then randomization for hydrotubation before IUI versus no hydrotubation was performed. Fifteen patients were cancelled from the study due to poor response or stimulation of three or more follicles. A total of 213 patients were randomized as follows: 103 patients undergoing hydrotubation using 50ml of saline and 110 patients with no hydrotubation. IUI was performed the following day and ongoing pregnancy occurred in 13 patients (12.6%) in the hydrotubation group and nine patients (8.2%) in the non-hydrotubation group with no significant difference (OR 1.66; 95% CI 0.62–4.63). In conclusion, hydrotubation before IUI does not improve pregnancy rate.

Keywords: hydrotubation, IUI, ovarian stimulation, pregnancy rate

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

 Mohamed Aboulghar obtained his Doctorate degree in Obstetrics and Gynecology in 1969 and has been Professor of Obstetrics and Gynecology in the Faculty of Medicine at Cairo University, Egypt since 1979. He continues to supervise post-graduate degrees there in Obstetrics and Gynecology and related subjects. He is also Clinical Director at the Egyptian IVF-ET Centre, Maadi, Cairo, Editor-in-Chief of the Middle East Fertility Society Journal and a regular reviewer for several international journals. He has organized scientific meetings in Egypt in collaboration with key European and American centres and has participated in many such meetings in the Middle East, Europe, and North America over the past 20years.

PII: S1472-6483(10)00004-0

doi:10.1016/j.rbmo.2010.01.003

Reproductive BioMedicine Online
Volume 20, Issue 4 , Pages 543-546, April 2010

Article Tools