Preimplantation genetic haplotyping: 127 diagnostic cycles demonstrating a robust, efficient alternative to direct mutation testing on single cells

Renwick, Pamela; Trussler, Jane; Lashwood, Alison; Braude, Peter; Ogilvie, Caroline Mackie

doi:10.1016/j.rbmo.2010.01.006

« Previous Next »Reproductive BioMedicine Online
Volume 20, Issue 4 , Pages 470-476, April 2010

Preimplantation genetic haplotyping: 127 diagnostic cycles demonstrating a robust, efficient alternative to direct mutation testing on single cells

Guy’s & St. Thomas’ Centre for Preimplantation Genetic Diagnosis and Genetics Centre, Guy’s & St. Thomas’ NHS Foundation Trust, London, UK

Received 27 February 2009; received in revised form 27 March 2009; accepted 16 December 2009. published online 08 February 2010.

Declaration of interest: The authors report no financial or commercial conflicts of interest.

To access this article, please choose from the options below

Pamela Renwick is a consultant clinical scientist and is head of the molecular genetic group within the Centre for Preimplantation Genetic Diagnosis at Guy’s and St. Thomas’ Hospital; this service provides preimplantation genetic diagnosis (PGD) for couples at risk of inherited single-gene defects. She introduced the approach of preimplantation genetic haplotyping in 2006 which won the centre a national Hospital Doctor award for innovation. She has recently joined the steering committee of the ESHRE PGD consortium.