Reproductive BioMedicine Online
Volume 20, Issue 5 , Pages 699-706 , May 2010

Administration of βHCG leads to dose-dependent changes of gene expression signature of endometriotic stromal cells

  • Gernot Hudelist

      Affiliations

    • Division of Special Gynecology, Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18–20, A-1090 Vienna, Austria
    • Department of OB/GYN, Center for Endometriosis, Villach General Hospital, Vienna, Austria
  • ,
  • Ambros Huber

      Affiliations

    • Division of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
  • ,
  • Michael Auer

      Affiliations

    • Ludwig Boltzmann Institute for Clinical and Experimental Oncology, Vienna, Austria
  • ,
  • Martin Knöfler

      Affiliations

    • Division of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
  • ,
  • Leila Saleh

      Affiliations

    • Division of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
  • ,
  • Christian Hrachowitz

      Affiliations

    • Department of Urology, Medical University of Vienna, Vienna, Austria
    • Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
  • ,
  • Johannes C. Huber

      Affiliations

    • Division of Endocrinology, Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
  • ,
  • Ernst Kubista

      Affiliations

    • Division of Special Gynecology, Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18–20, A-1090 Vienna, Austria
    • Ludwig Boltzmann Institute for Clinical and Experimental Oncology, Vienna, Austria
  • ,
  • Mahmood Manavi

      Affiliations

    • Division of Special Gynecology, Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18–20, A-1090 Vienna, Austria
  • ,
  • Martin Bilban

      Affiliations

    • Clinical Institute for Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
  • ,
  • Christian F. Singer

      Affiliations

    • Division of Special Gynecology, Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18–20, A-1090 Vienna, Austria
    • Ludwig Boltzmann Institute for Clinical and Experimental Oncology, Vienna, Austria
    • Corresponding Author InformationCorresponding author.

Received 11 December 2008 ,Revised 29 January 2009 ,Accepted 10 December 2009.

References 

  1. Ballard K, Lowton K, Wright J. What’s the delay? A qualitative study of women’s experiences of reaching a diagnosis of endometriosis. Fertil. Steril. 2006;86:1296–1301
  2. Bruse C, Radu D, Bergqvist A. In situ localization of mRNA for the fibrinolytic factors uPA, PAI-1 and uPAR in endometriotic and endometrial tissue. Mol. Hum. Reprod. 2004;10:159–166
  3. Chegini N, Kotseos K, Zhao Y, et al. Expression of matrix metalloproteinase (MMP1) and tissue inhibitor of MMP in serosal tissue of intraperitoneal organs and adhesions. Fertil. Steril. 2001;76:1212–1219
  4. Chung HW, Wen Y, Chun SH, Nezhat C, Woo BH, Lake Polan M. Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-3 mRNA expression in ectopic and eutopic endometrium in women with endometriosis: a rationale for endometriotic invasiveness. Fertil. Steril. 2001;75:152–159
  5. ESHRE, 2008. The ESHRE Guideline on Endometriosis 2008.
  6. Fox BP, Tabone CJ, Kandpal RP. Potential clinical relevance of Eph receptors and ephrin ligands expressed in prostate carcinoma cell lines. Biochem. Biophys. Res. Commun. 2006;342:1263–1272
  7. Gottschalk C, Malberg K, Arndt M, et al. Matrix metalloproteinases and TACE play a role in the pathogenesis of endometriosis. Adv. Exp. Med. Biol. 2000;477:483–486
  8. Huber AV, Huber JC, Kolbus A, et al. Systemic HCG treatment in patients with endometriosis: a new perspective for a painful disease. Wien. Klin. Wochenschr. 2004;116:839–843
  9. Huber A, Hudelist G, Knofler M, Saleh L, Huber JC, Singer CF. Effect of highly purified human chorionic gonadotropin preparations on the gene expression signature of stromal cells derived from endometriotic lesions: potential mechanisms for the therapeutic effect of human chorionic gonadotropin in vivo. Fertil. Steril. 2007;88:1232–1239
  10. Hudelist G, Lass H, Keckstein J, et al. Interleukin 1alpha and tissue-lytic matrix metalloproteinase-1 are elevated in ectopic endometrium of patients with endometriosis. Hum. Reprod. 2005;20:1695–1701
  11. Huynh KM, Kim G, Kim DJ, et al. Gene expression analysis of terminal differentiation of human melanoma cells highlights global reductions in cell cycle-associated genes. Gene. 2009;433:32–39
  12. Irizarry RA, Hobbs B, Collin F, et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 2003;4:249–264
  13. Jones KD, Sutton C. Patient satisfaction and changes in pain scores after ablative laparoscopic surgery for stage III–IV endometriosis and endometriotic cysts. Fertil. Steril. 2003;79:1086–1090
  14. Kawamura C, Kizaki M, Yamato K, et al. Bone morphogenetic protein-2 induces apoptosis in human myeloma cells with modulation of STAT3. Blood. 2000;96:2005–2011
  15. Keckstein J, Ulrich U, Kandolf O, Wiesinger H, Wustlich M. Laparoscopic therapy of intestinal endometriosis and the ranking of drug treatment. Zentralbl. Gynakol. 2003;125:259–266
  16. Kikuchi I, Takeuchi H, Kitade M, Shimanuki H, Kumakiri J, Kinoshita K. Recurrence rate of endometriomas following a laparoscopic cystectomy. Acta Obstet. Gynecol. Scand. 2006;85:1120–1124
  17. Koga K, Takemura Y, Osuga Y, Yoshino O, Hirota Y, Hirata T, et al. Recurrence of ovarian endometrioma after laparoscopic excision. Hum. Reprod. 2006;21:2171–2174
  18. Kokorine I, Marbaix E, Henriet P, Okada Y, Donnez J, Eeckhout Y, et al. Focal cellular origin and regulation of interstitial collagenase (matrix metalloproteinase-1) are related to menstrual breakdown in the human endometrium. J. Cell Sci. 1996;109:2151–2160
  19. Melis GB, Ajossa S, Guerriero S, Paoletti AM, Angiolucci M, Piras B, et al. Epidemiology and diagnosis of endometriosis. Ann. NY Acad. Sci. 1994;734:352–357
  20. Mentink-Kane MM, Wynn TA. Opposing roles for IL-13 and IL-13 receptor alpha 2 in health and disease. Immunol. Rev. 2004;202:191–202
  21. Olive DL, Pritts EA. The treatment of endometriosis: a review of the evidence. Ann. NY Acad. Sci. 2002;955:360–372discussion 389–93, 396–406
  22. Parker JD, Leondires M, Sinaii N, Premkumar A, Nieman LK, Stratton P. Persistence of dysmenorrhea and nonmenstrual pain after optimal endometriosis surgery may indicate adenomyosis. Fertil. Steril. 2006;86:711–715
  23. Pilcher BK, Sudbeck BD, Dumin JA, Welgus HG, Parks WC. Collagenase-1 and collagen in epidermal repair. Arch. Dermatol. Res. 1998;290(Suppl.):S37–S46
  24. Prentice A, Deary AJ, Bland E. Progestagens and anti-progestagens for pain associated with endometriosis. Cochrane Database Syst. Rev. 2000;CD002122
  25. Schroder AK, Diedrich K, Ludwig M. Medical management of endometriosis: a systematic review. IDrugs. 2004;7:451–463
  26. Wang HT, Kong JP, Ding F, Wang XQ, Wang MR, Liu LX, et al. Analysis of gene expression profile induced by EMP-1 in esophageal cancer cells using cDNA microarray. World J. Gastroenterol. 2003;9:392–398
  27. Yin L, Fu S, Zhao X, Garcia-Sanchez F, Deisseroth AB. Correlation of cell proliferation inhibition and apoptosis induction with expression of human beta 5 integrin on hematopoietic cells. Chin. Med. J. (Engl.). 1999;112:659–664

 Dr Singer is a board-certified gynaecologist and professor at the Medical University of Vienna. After graduation from Innsbruck University Medical School he successfully completed postdoctoral fellowships at Georgetown University (USA) and at the University of Leuven (Belgium), where he studied the influence of hormones on the development of malignant tumours. Professor Singer works and teaches at the Medical University of Vienna, where he has specialized in the treatment of breast cancer and the alleviation of climacteric symptoms. He was appointed Associated Professor of Obstetrics and Gynecology in 2004 and directs the clinic for hereditary breast and ovarian cancer at the Vienna General Hospital.

PII: S1472-6483(10)00046-5

doi: 10.1016/j.rbmo.2010.01.010

Reproductive BioMedicine Online
Volume 20, Issue 5 , Pages 699-706 , May 2010