Reproductive BioMedicine Online
Volume 24, Issue 2 , Pages 251-253, February 2012

Absence of SYCP3 mutations in women with recurrent miscarriage with at least one trisomic miscarriage

  • Courtney W. Hanna

      Affiliations

    • Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    • These authors contributed equally to this work.
    • ,
  • John D. Blair

      Affiliations

    • Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    • These authors contributed equally to this work.
    • ,
  • Mary D. Stephenson

      Affiliations

    • Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA
    • Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada V6H 3N1
    • ,
  • Wendy P. Robinson

      Affiliations

    • Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    • Corresponding Author InformationCorresponding author.

Received 20 June 2011; received in revised form 20 October 2011; accepted 26 October 2011. published online 04 November 2011.

Declaration: The authors report no financial or commercial conflicts of interest.

Abstract 

Mutations within the coding regions of the synaptonemal complex gene SYCP3 have previously been reported in women with recurrent miscarriage. The present study found no mutations in any of the coding exons or the intron/exon boundaries among 50 recurrent miscarriage patients with at least one documented trisomic miscarriage, suggesting that mutations in SYCP3 do not contribute significantly to risk for recurrent miscarriage through maternal meiotic nondisjunction.

Keywords: mutations, nondisjunction, recurrent miscarriage, SYCP3, trisomy

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 Courtney W Hanna obtained her degree in integrated sciences at the University of British Columbia. She is currently a PhD candidate at the same university and is working on genetics of recurrent miscarriage. She is funded by the Canadian Institutes of Health Research.

PII: S1472-6483(11)00599-2

doi:10.1016/j.rbmo.2011.10.013

Reproductive BioMedicine Online
Volume 24, Issue 2 , Pages 251-253, February 2012

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