Abstract
Cabergoline, a dopamine receptor-2 agonist, is suggested to prevent ovarian hyperstimulation
syndrome (OHSS) during ovarian stimulation. The aim of this study was to evaluate
the influence of different timing of cabergoline administration on clinical outcome
among patients at risk of developing OHSS. Among infertile women undergoing IVF treatment
at risk of developing OHSS, 206 were enrolled in this study. The subjects were randomly
allocated into two groups, i.e. the study group (n = 100) receiving cabergoline beginning on the day of human chorionic gonadotrophin (HCG)
injection and the control group (n = 100) receiving cabergoline starting on the day of oocyte retrieval. Oocyte metaphase-II
rate, fertilization rate, clinical outcome and incidence of severe OHSS were compared
between the two groups. There were no significant differences in oocyte metaphase-II
rate (0.86 ± 0.16 versus 0.85 ± 0.15) or fertilization rate (0.79 ± 0.22 versus 0.76 ± 0.20) or in the incidence of OHSS between two groups. Similarly, there were no significant
differences in implantation or clinical pregnancy rate between the two groups. Cabergoline
can be administered as soon as HCG injection to prevent early OHSS, without adverse
effects on oocyte maturation, fertilization rate and clinical outcome.
Cabergoline, a dopamine receptor-2 agonist, is suggested to prevent ovarian hyperstimulation
syndrome (OHSS) during ovarian stimulation. Nevertheless, the most suitable timing
of cabergoline administration has not yet been studied. The aim of this study was
to evaluate the influence of different timing of cabergoline administration on final
oocyte maturation, fertilization rate and clinical outcome among patients at risk
of developing OHSS. Among infertile women undergoing IVF treatment at risk of developing
OHSS, 206 were enrolled in this study. The subjects were randomly allocated into two
groups, i.e. the study group (n = 100) receiving cabergoline beginning on the day of human chorionic gonadotrophin (HCG)
injection and the control group (n = 100) receiving cabergoline starting on the day of oocyte retrieval. Oocyte metaphase
II rate, fertilization rate, clinical outcome and incidence of severe OHSS were compared
between the two groups. There were no significant differences in oocyte metaphase
II rate (0.86 ± 0.16 versus 0.85 ± 0.15) or fertilization rate (0.79 ± 0.22 versus 0.76 ± 0.20) or in the incidence of OHSS (3/100 versus 1/100) between the control and study
groups. Similarly, there were no significant differences in implantation rate (36.6%
versus 34.0%) or clinical pregnancy rate (54.0% versus 51.0%) between the two groups.
Among women at high risk of OHSS, cabergoline can be administered as soon as the HCG
injection to prevent early OHSS, without adverse effects on oocyte maturation, fertilization
rate and clinical outcome.
Keywords
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Article info
Publication history
Published online: March 25, 2013
Accepted:
March 12,
2013
Received in revised form:
March 6,
2013
Received:
October 22,
2012
Declaration: The authors report no financial or commercial conflicts of interest.Footnotes
Kok-Min Seow received his MD degree from the National Yang-Ming University, Taiwan in 1996. After completing residency training at the Shin-Kong Wu Ho-Su Memorial Hospital, he served as an attending physician at the Shin-Kong Wu Ho-Su Memorial Hospital. In 2007, he obtained his PhD degree from the department of clinical medicine, National Yang-Ming University. He is also an assistant professor at the school of medicine, National Yang-Ming University. His clinical interests include prenatal ultrasound diagnosis and laparoscopic surgery and his research interest is insulin resistance in polycystic ovary syndrome.
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© 2013 Reproductive Healthcare Ltd. Published by Elsevier Inc. All rights reserved.
