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Successful treatment of an aggressive recurrent post-menopausal endometriosis with an aromatase inhibitor

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      Abstract

      The current case report describes the development and medical treatment of an aggressive pelvic endometrioma in a post-menopausal patient, who had undergone abdominal hysterectomy and salpingo-oophorectomy a decade earlier. The patient was referred to the authors’ centre because of right-sided sciatic pain. Three months before her admission she was hospitalized elsewhere due to subacute bowel obstruction. She was operated on and a resection of a part of sigmoid colon and an endometrioma, which was the cause of the subobstruction, was carried out. During the clinical investigation for the right-sided sciatic pain, an intrapelvic mass was found, which was compressing the lumbo–sacral plexus mimicking sciatica. The diagnosis of recurrent endometrioma was confirmed by a computerized tomography-guided biopsy and the decision was made to treat it with an aromatase inhibitor (letrozole). Eighteen months later, the endometrioma was almost completely regressed and the patient was free of symptoms. Medical management of recurrent post-menopausal endometriosis with aromatase inhibitors seems to be an effective alternative treatment to surgery.

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      References

        • Bulun SE
        • Gurates B
        • Fang Z
        • et al.
        Mechanisms of excessive estrogen formation in endometriosis.
        Journal of Reproductive Immunology. 2002; 55: 21-33
        • Child TJ
        • Tan SL
        Endometriosis: etiology, pathogenesis and treatment.
        Drugs. 2001; 61: 1735-1750
        • Deval B
        • Rafii A
        • Felce Dachez M
        • et al.
        Sigmoid endometriosis in a postmenopausal woman.
        American Journal of Obstetrics and Gynecology. 2002; 187: 1723-1725
        • Dogan E
        • Saygili U
        • Posaci C
        • et al.
        Regression of endometrial explants in rats with cyclooxyoxgenase-2 rofecoxib.
        Fertility and Sterility. 2004; 82: 1115-1120
        • Fatemi HM
        • Kolibianakis E
        • Tournaye H
        • et al.
        Clomiphene citrate versus letrozole for ovarian stimulation: a pilot study.
        Reproductive BioMedicine Online. 2003; 7: 543-546
        • Goumenou AG
        • Chow C
        • Taylor A
        • Magos A
        Endometriosis arising during estrogen and testosterone treatment 17 years after abdominal hysterectomy: a case report.
        Maturitas. 2003; 46: 239-241
        • Noble LS
        • Simpson ER
        • Johns A
        • Bulun SE
        Aromatase expression in endometriosis.
        The Journal of Clinical Endocrinology and Metabolism. 1996; 81: 174-179
        • Olive DL
        • Lindheim SR
        • Pritts EA
        New medical treatments for endometriosis.
        Best Practice and Research Clinical Obstetrics and Gynecology. 2004; 18: 319-328
        • Razzi S
        • Fava A
        • Sartini A
        • De Simone S
        • et al.
        Treatment of severe recurrent endometriosis with an aromatase inhibitor in a young ovariectomised woman.
        British Journal of Obstetrics and Gynecology. 2004; 111: 182-184
        • Soysal S
        • Soysal ME
        • Ozer S
        • et al.
        The effects of post-surgical administration of goserelin plus anastrozole compared to goserelin alone in patients with severe endometriosis: a prospective randomized trial.
        Human Reproduction. 2004; 19: 160-167
        • Takayama K
        • Zeitoun K
        • Gunby RT
        • et al.
        Treatment of severe postmenopausal endometriosis with an aromatase inhibitor.
        Fertility and Sterility. 1998; 69: 709-713

      Biography

      Dr Human Mousavi Fatemi obtained his MD degree in 1999 at the Free University of Brussels. In 2004 he finished his specialization in gynaecology, andrology and obstetrics. Currently he is working as a consultant at the Centre of Reproductive Medicine at the Dutch-speaking Free University of Brussels. His special interest is in reproductive surgery (laparoscopy/hysteroscopy). His research areas are the luteal phase in assisted reproduction technology and the use of aromatase inhibitors. Currently he is working towards his PhD degree on the luteal phase in stimulated cycles.