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Insights into human endometrial receptivity from transcriptomic and proteomic data

  • Delphine Haouzi
    Affiliations
    CHU Montpellier, Institut de Recherche en Biothérapie, INSERM U847, Hôpital Saint-Eloi, 80 avenue Augustin Fliche, F-34295 Montpellier cedex 5, France

    CHU Montpellier, ART/PGD Division, Département de Médecine et Biologie de la Reproduction, Hôpital Arnaud de Villeneuve, 371 avenue du Doyen Gaston Giraud, F-34295 Montpellier cedex 5, France

    Université Montpellier1, UFR de Médecine, Laboratoire ‘Développement embryonnaire précoce et cellules souches embryonnaires humaines’, F-34000 Montpellier, France
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  • Hervé Dechaud
    Affiliations
    CHU Montpellier, Institut de Recherche en Biothérapie, INSERM U847, Hôpital Saint-Eloi, 80 avenue Augustin Fliche, F-34295 Montpellier cedex 5, France

    CHU Montpellier, ART/PGD Division, Département de Médecine et Biologie de la Reproduction, Hôpital Arnaud de Villeneuve, 371 avenue du Doyen Gaston Giraud, F-34295 Montpellier cedex 5, France

    Université Montpellier1, UFR de Médecine, Laboratoire ‘Développement embryonnaire précoce et cellules souches embryonnaires humaines’, F-34000 Montpellier, France
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  • Said Assou
    Affiliations
    CHU Montpellier, Institut de Recherche en Biothérapie, INSERM U847, Hôpital Saint-Eloi, 80 avenue Augustin Fliche, F-34295 Montpellier cedex 5, France

    CHU Montpellier, ART/PGD Division, Département de Médecine et Biologie de la Reproduction, Hôpital Arnaud de Villeneuve, 371 avenue du Doyen Gaston Giraud, F-34295 Montpellier cedex 5, France

    Université Montpellier1, UFR de Médecine, Laboratoire ‘Développement embryonnaire précoce et cellules souches embryonnaires humaines’, F-34000 Montpellier, France
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  • John De Vos
    Affiliations
    CHU Montpellier, Institut de Recherche en Biothérapie, INSERM U847, Hôpital Saint-Eloi, 80 avenue Augustin Fliche, F-34295 Montpellier cedex 5, France

    Université Montpellier1, UFR de Médecine, Laboratoire ‘Développement embryonnaire précoce et cellules souches embryonnaires humaines’, F-34000 Montpellier, France
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  • Samir Hamamah
    Correspondence
    Corresponding author.
    Affiliations
    CHU Montpellier, Institut de Recherche en Biothérapie, INSERM U847, Hôpital Saint-Eloi, 80 avenue Augustin Fliche, F-34295 Montpellier cedex 5, France

    CHU Montpellier, ART/PGD Division, Département de Médecine et Biologie de la Reproduction, Hôpital Arnaud de Villeneuve, 371 avenue du Doyen Gaston Giraud, F-34295 Montpellier cedex 5, France

    Université Montpellier1, UFR de Médecine, Laboratoire ‘Développement embryonnaire précoce et cellules souches embryonnaires humaines’, F-34000 Montpellier, France
    Search for articles by this author
Published:September 28, 2011DOI:https://doi.org/10.1016/j.rbmo.2011.09.009

      Abstract

      The appreciation of endometrial receptivity is a crucial step in assisted reproductive technology as implantation failures are thought to result, in large part, from abnormal endometrial receptivity. Using emerging omics technologies, investigators have begun to define both molecular signatures and specific biomarkers of receptive endometrium. The aim of this review was to analyse the new perspectives brought to the appreciation of endometrial receptivity by transcriptomic and proteomic technologies, involving the analysis of gene- or protein-expression-profile shifts between the pre-receptive and receptive secretory stages and how they might lead to new strategies for endometrial receptivity assessments. The use of omics as molecular tools to determine the effects of stimulation protocols on endometrial gene expression and clinical outcomes has also been investigated.
      The appreciation of endometrial receptivity is a crucial step in assisted reproductive technology as implantation failures are thought to result, in large part, from abnormal endometrial receptivity. Using emerging omics technologies, investigators have begun to define both molecular signatures and specific biomarkers of receptive endometrium. The aim of this review is to analyse the new perspectives brought to the appreciation of endometrial receptivity by omics technologies, involving the analysis of gene- or protein-expression-profile shifts between the pre-receptive and receptive secretory stages, and how they might lead to new strategies for endometrial receptivity assessments. The use of omics during IVF procedures as molecular tools to determine the effects of stimulation protocols on endometrial gene expression and clinical outcomes has also been investigated.

      Keywords

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