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Article| Volume 38, ISSUE 2, P260-271, February 2019

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The use of home remedies and complementary health approaches in endometriosis

Published:December 14, 2018DOI:https://doi.org/10.1016/j.rbmo.2018.10.009

      Abstract

      Research question

      Conventional treatments are often associated with adverse effects and endometriosis pain symptoms may reoccur despite treatment. Consequently, many women use complementary health approaches (CHA) and home remedies (HR) to relieve their pain. The aim of this study was to examine the frequency and the subjectively perceived efficacy of CHA/HR use by women affected by endometriosis.

      Design

      Retrospective evaluation using medical charts and a questionnaire. Women recruited in hospitals and in self-help groups were asked about the use of ‘topical heat’, ‘repose/relaxation’, ‘movement/massages’, ‘homeopathy/phytotherapy’, ‘acupuncture/traditional Chinese medicine (TCM)’ and ‘kinesiology/physiotherapy’.

      Results

      From a total of 574 women with a confirmed diagnosis of endometriosis, 359 (62.5%) applied some form of CHA/HR. Women suffering from fatiguing disease symptoms more often selected alternative therapies (odds ratio [OR] 3.14, 95% confidence interval [CI] 1.39–7.11, P = 0.006) compared with women without these characteristics. Furthermore, women dissatisfied with healthcare provided by their treating physician, more frequently (OR 2.30, 95% CI 1.19–4.45, P = 0.013) chose the aforementioned alternative strategies.

      Conclusion

      As conventional therapies may not be sufficiently effective, women's needs should be closely examined, and individual treatment options should be discussed and initiated by clinicians to provide the best comprehensive treatment possible for endometriosis.

      Keywords

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      References

        • Abbott J.A.
        • Hawe J.
        • Clayton R.D.
        • Garry R.
        The effects and effectiveness of laparoscopic excision of endometriosis: a prospective study with 2–5 year follow-up.
        Hum. Reprod. 2003; 18: 1922-1927
        • Agarwal S.K.
        • Hamrang C.
        • Henzl M.R.
        • Judd H.L.
        Nafarelin versus leuprolide acetate depot for endometriosis. Changes in bone mineral density and vasomotor symptoms. Nafarelin Study Group.
        J. Reprod. Med. 1997; 42: 413-423
        • Akin M.D.
        • Weingand K.W.
        • Hengehold D.A.
        • Goodale M.B.
        • Hinkle R.T.
        • Smith R.P.
        Continuous low-level topical heat in the treatment of dysmenorrhoea.
        Obstetrics and Gynecology. 2001; 97: 343-349
        • Allen C.
        • Hopewell S.
        • Prentice A.
        • Gregory D.
        Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis.
        Cochrane Database of Systematic Reviews. 2009;
        • As-Sanie S.
        • Harris R.E.
        • Napadow V.
        • Kim J.
        • Neshewat G.
        • Kairys A.
        • Williams D.
        • Clauw D.J.
        • Schmidt-Wilcke T.
        Changes in regional gray matter volume in women with chronic pelvic pain: A voxel-based morphometry study.
        Pain. 2012; 153: 1006-1014
        • Barbieri R.L.
        • Evans S.
        • Kistner R.W.
        Danazol in the treatment of endometriosis: analysis of 100 cases with a 4-year follow-up.
        Fertil. Steril. 1982; 37: 737-746
        • Becker C.M.
        • Gattrell W.T.
        • Gude K.
        • Singh S.S.
        Reevaluating response and failure of medical treatment of endometriosis: a systemic review.
        Fertil. Steril. 2017; 108: 125-136
        • Brawn J.
        • Morotti M.
        • Zondervan K.T.
        • Becker C.M.
        • Vincent K.
        Central changes associated with chronic pelvic pain and endometriosis.
        Human Reproduction Update. 2014; 20: 737-747
        • Brauer C.
        • Thomsen J.F.
        • Loft I.P.
        • Mikkelsen S.
        Can we rely on retrospective pain assessments?.
        Am. J. Epidemiol. 2003; 157: 552-557
        • Bulun S.E.
        Endometriosis.
        New England Journal of Medicine. 2009; 360: 268-279
        • Chao M.T.
        • Abercrombie P.D.
        • Nakagawa S.
        • Gregorich S.E.
        • Learman L.A.
        • Kuppermann M.
        Prevalence and use of complementary health approaches among women with chronic pelvic pain in a prospective cohort study.
        Pain. Med. 2015; 16: 328-340
        • Chen L.
        • Michalsen A.
        Management of chronic pain using complementary and integrative medicine.
        BMJ. 2017; 357: j1284
        • Cox H.
        • Henderson L.
        • Wood R.
        • Cagliarini G.
        Learning to take charge: Women's experiences of living with endometriosis.
        Complementary Therapies in Nursing and Midwifery. 2003; 9: 62-68
        • Domoney C.L.
        • Vashisht A.
        • Studd J.W.W.
        Use of complementary therapies by women attending a specialist premenstrual syndrome clinic.
        Gynecological Endocrinology. 2003; 17: 13-18
        • Drossman D.A.
        • Camilleri M.
        • Mayer E.A.
        • Whitehead W.E.
        AGA technical review on irritable bowel syndrome.
        Gastroenterology. 2002; 6 (123): 2108-2131
        • Dunselman G.A.
        • Vermeulen N.
        • Becker C.
        • Calhaz-Jorge C.
        • D'Hooghe T.
        • De Bie B.
        • Heikinheimo O.
        • Horne A.W.
        • Kiesel L.
        • Nap A.
        • Prentice A.
        • Saridogan E.
        • Soriano D.
        • Nelen W.
        • European Society of Human Reproduction and Embryology
        ESHRE guideline: Management of women with endometriosis.
        Human Reproduction. 2014; 29: 400-412
        • Falcone T.
        • Shakiba K.
        • Bena J.F.
        • McGill K.M.
        • Minger J.
        Surgical treatment of endometriosis: A 7-year follow-up on the requirement for further surgery.
        Obstetrics and Gynecology. 2008; 111: 1285-1292
        • Fedele L.
        • Somigliana E.
        • Frontino G.
        • Benaglia L.
        • Vigano P.
        New drugs in development for the treatment of endometriosis.
        Expert Opin. Investig. Drugs. 2008; 17: 1187-1202
        • Fisher C.
        • Sibbritt D.
        • Hickman L.
        • Adams J.
        A critical review of complementary and alternative medicine use by women with cyclic perimenstrual pain and discomfort: a focus upon prevalence, patterns and applications of use and users’ motivations, information seeking and self-perceived efficacy.
        Acta Obstetricia et Gynecologica Scandinavica. 2016; 95: 861-871
        • Fisher C.
        • Adams J.
        • Hickman L.
        • Sibbritt D.
        The use of complementary and alternative medicine by 7427 Australian women with cyclic perimenstrual pain and discomfort: a cross-sectional study.
        BMC Complement Altern. Med. 2016; 16: 129
        • Fox S.D.
        • Flynn E.
        • Allen R.H.
        Mindfulness meditation for women with chronic pelvic pain: A pilot study.
        Journal of Reproductive Medicine. 2011; 56: 158-162
        • Furuse N.
        • Shinbara H.
        • Uehara A.
        • Sugawara M.
        • Yamazyki T.
        • Hosaka M.
        • Ymashita H.
        A Multicentre Prospective Survey of Adverse Events Associated with Acupuncture and Moxibustion in Japan.
        Medical Acupuncture. 2017; 29: 155-162
        • Giudice L.C.
        • Kao L.C.
        Endometriosis.
        Lancet. 2004; 364: 1789-1799
        • Gronblad M.
        • Hupli M.
        • Wennerstrand P.
        • Jarvinen E.
        • Lukinmaa A.
        • Kouri J.P.
        • Karaharju E.O.
        Intercorrelation and test-retest reliability of the Pain Disability Index (PDI) and the Oswestry Disability Questionnaire (ODQ) and their correlation with pain intensity in low back pain patients.
        Clinical Journal of Pain. 1993; 9: 189-195
        • Guo S.W.
        Recurrence of endometriosis and its control.
        Human Reproduction Update. 2009; 15: 441-461
        • Haemmerli S.
        • Kohl Schwartz A.S.
        • Geraedts K.
        • Imesch P.
        • Rauchfuss M.
        • Woelfler M.M.
        • Haeberlin F.
        • von Orelli S.
        • Eberhard M.
        • Imthurn B.
        • Leeners B.
        Does endometriosis affect sexual activity and satisfaction of the male partner?.
        J. Sex Med. 2018; https://doi.org/10.1016/j.jsxm.2018.03.087
        • Hansen K.E.
        • Kesmodel U.S.
        • Baldursson E.B.
        • Kold M.
        • Forman A.
        Visceral syndrome in endometriosis patients.
        European Journal of Obstetrics Gynecology and Reproductive Biology. 2014; 179: 198-203
        • Harrison R.F.
        • Barry-Kinsella C.
        Efficacy of medroxyprogesterone treatment in infertile women with endometriosis: a prospective, randomized, placebo-controlled study.
        Fertil. Steril. 2000; 74: 24-30
        • Highfield E.S.
        • Laufer M.R.
        • Schnyer R.N.
        • Kerr C.E.
        • Thomas P.
        • Wayne P.M.
        Adolescent endometriosis-related pelvic pain treated with acupuncture: Two case reports.
        Journal of Alternative and Complementary Medicine. 2006; 12: 317-322
        • Hur M.H.
        • Lee M.S.
        • Seong K.Y.
        • Lee M.K.
        Aromatherapy massage on the abdomen for alleviating menstrual pain in high school girls: A preliminary controlled clinical study.
        Evidence-based Complementary and Alternative Medicine. 2012; 2012
        • Kavoussi S.K.
        • Lim C.S.
        • Skinner B.D.
        • Lebovic D.I.
        • As-Sanie S.
        New paradigms in the diagnosis and management of endometriosis.
        Current Opinion in Obstetrics and Gynecology. 2016; 28: 267-276
        • Kennedy S.
        • Bergqvist A.
        • Chapron C.
        • D'Hooghe T.
        • Dunselman G.
        • Greb R.
        • Hummelshoj L.
        • Prentice A.
        • Saridogan E.
        • ESHRE Special Interest Group for Endometriosis and Endometrium Guideline Development Group
        ESHRE guideline for the diagnosis and treatment of endometriosis.
        Human Reproduction. 2005; 20: 2698-2704
        • Kohl Schwartz A.S.
        • Woelfler M.
        • Mitter V.
        • Rauchfuss M.
        • Haeberlin F.
        • Eberhard M.
        • von Orelli S.
        • Imthurn B.
        • Imesch P.
        • Fink D.
        • Leeners B.
        Endometriosis, especially mild disease: a risk factor for miscarriages.
        Fertil. Steril. 2017; 108: 806-814
        • Kong S.
        • Zhang Y.H.
        • Liu C.F.
        • Tsui I.
        • Guo Y.
        • Ai B.B.
        • Han F.J.
        The complementary and alternative medicine for endometriosis: A review of utilization and mechanism.
        Evidence-based Complementary and Alternative Medicine. 2014; 2014
        • Kuppermann M.
        • Learman L.A.
        • Schembri M.
        • Gregorich S.
        • Jacoby A.
        • Jackson R.A.
        • Gates E.
        • Wassel-Fyr C.
        • Lewis J.
        • Washington A.E.
        Effect of noncancerous pelvic problems on health-related quality of life and sexual functioning.
        Obstetrics and Gynecology. 2007; 110: 633-642
        • La Cour P.
        • Petersen M.
        Effects of Mindfulness Meditation on Chronic Pain: A Randomized Controlled Trial.
        Pain Medicine (United States). 2015; 16: 641-652
        • Laschke M.W.
        • Menger M.D.
        Anti-angiogenic treatment strategies for the therapy of endometriosis.
        Hum Reprod Update. 2012; 18: 682-702
        • Leeners B.
        • Imthurn B.
        Psychosomatic aspects of endometriosis Current state of scientific knowledge and clinical experience.
        Gyn-geburtshliche Rundschau. 2007; 47: 132-139
        • Leeners B.
        • Damaso F.
        • Ochsenbein-Kölble N.
        • Farquhar C.
        The effect of pregnancy on endometriosis-facts or fiction?.
        Hum. Reprod. Update. 2018; in press;
        • Leong F.C.
        Complementary and alternative medications for chronic pelvic pain.
        Obstetrics and Gynecology Clinics of North America. 2014; 41: 503-510
        • Liebermann C.
        • Kohl Schwartz A.S.
        • Charpidou T.
        • Geraedts K.
        • Rauchfuss M.
        • Woelfler M.M.
        • von Orelli S.
        • Haeberlin F.
        • Eberhard M.
        • Imesch P.
        • Imthurn B.
        • Leeners B.
        Maltreatment during childhood: a risk factor for the development of endometriosis?.
        Hum. Reprod. 2018; in press;
        • Ling F.W.
        Randomized controlled trial of depot leuprolide in patients with chronic pelvic pain and clinically suspected endometriosis. Pelvic Pain Study Group.
        Obstet. Gynecol. 1999; 93: 51-58
        • Lund I.
        • Lundeberg T.
        Is acupuncture effective in the treatment of pain in endometriosis?.
        Journal of Pain Research. 2016; 9: 157-165
        • Missmer S.A.
        • Bove G.M.
        A pilot study of the prevalence of leg pain among women with endometriosis.
        Journal of Bodywork and Movement Therapies. 2011; 15: 304-308
        • Nisolle-Pochet M.
        • Casanas-Roux F.
        • Donnez J.
        Histologic study of ovarian endometriosis after hormonal therapy.
        Fertil. Steril. 1988; 49: 423-426
        • Osayande A.S.
        • Mehulic S.
        Diagnosis and initial management of dysmenorrhoea.
        American Family Physician. 2014; 89: 341-346
        • Pellino T.A.
        • Ward S.E.
        Perceived control mediates the relationship between pain severity and patient satisfaction.
        J Pain Symptom Manage. 1998; 15: 110-116
        • Rakhshaee Z.
        Effect of Three Yoga Poses (Cobra, Cat and Fish Poses) in Women with Primary Dysmenorrhoea: A Randomized Clinical Trial.
        Journal of Pediatric and Adolescent Gynecology. 2011; 24: 192-196
      1. Ramin-Wright, A., Kohl Schwartz, A.S., Geraedts, K., Rauchfuss, M., Woellfler, M.M., Haeberlin, F., von Orelli, S., Eberhard, M., Imthurn, B., Imesch, P., Fink, D., Leeners, B. Fatigue – an underestimated symptom in endometriosis, Human Reproduction. 2018; in press.

        • Roshni P.
        • Suneetha Susan Cleave A.
        • Suresh P.K.
        Complementary and alternative medicine (CAM) therapies for management of pain related to endometriosis.
        International Research Journal of Pharmacy. 2012; 3: 30-34
        • Rubi-Klein K.
        • Kucera-Sliutz E.
        • Nissel H.
        • Bijak M.
        • Stockenhuber D.
        • Fink M.
        • Wolkenstein E.
        Is acupuncture in addition to conventional medicine effective as pain treatment for endometriosis?: A randomized controlled crossover trial.
        European Journal of Obstetrics Gynecology and Reproductive Biology. 2010; 153: 90-93
        • Schenken R.S.
        • Guzick D.S.
        Revised endometriosis classification: 1996.
        Fertil Steril. 1997; 67: 815-816
        • Soares S.R.
        • Martinez-Varea A.
        • Hidalgo-Mora J.J.
        • Pellicer A.
        Pharmacologic therapies in endometriosis: A systematic review.
        Fertility and Sterility. 2012; 98: 529-555
        • Stratton P.
        • Berkley K.J.
        Chronic pelvic pain and endometriosis: Translational evidence of the relationship and implications.
        Human Reproduction Update. 2011; 17: 327-346
        • Strowitzki T.
        • Marr J.
        • Gerlinger C.
        • Faustmann T.
        • Seitz C.
        Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial.
        Hum. Reprod. 2010; 25: 633-641
        • Sukhato K.
        • Lotrakul M.
        • Dellow A.
        • Ittasakul P.
        • Thakkinstian A.
        • Anothaisintawee T.
        Efficacy of home-based non-pharmacological interventions for treating depression: a systematic review and network meta-analysis of randomized controlled trials.
        BMJ Open. 2017; 7 (12)e014499
        • Tait R.C.
        • Chibnall J.T.
        • Krause S.
        The Pain Disability Index: Psychometric properties.
        Pain. 1990; 40: 171-182
        • Tan G.
        • Jensen M.P.
        • Thornby J.I.
        • Shanti B.F.
        Validation of the brief pain inventory for chronic nonmalignant pain.
        Journal of Pain. 2004; 5: 133-137
        • Taylor R.N.
        • Hummelshoj L.
        • Stratton P.
        • Vercellini P.
        Pain and endometriosis: aetiology, impact, and therapeutics.
        Middle East Fertility Society Journal. 2012; 17: 221-225
        • Teixeira M.E.
        Meditation as an intervention for chronic pain: an integrative review.
        Holistic nursing practice. 2008; 22: 225-234
        • Vercellini P.
        • Aimi G.
        • Panazza S.
        • De Giorgi O.
        • Pesole A.
        • Crosignani P.G.
        A levonorgestrel-releasing intrauterine system for the treatment of dysmenorrhoea associated with endometriosis: a pilot study.
        Fertil. Steril. 1999; 72: 505-508
        • Vercellini P.
        • Barbara G.
        • Somigliana E.
        • Bianchi S.
        • Abbiati A.
        • Fedele L.
        Comparison of contraceptive ring and patch for the treatment of symptomatic endometriosis.
        Fertil. Steril. 2010; 93: 2150-2161
        • Vercellini P.
        • Bracco B.
        • Mosconi P.
        • Roberto A.
        • Alberico D.
        • Dhouha D.
        • Somigliana E.
        Norethindrone acetate or dienogest for the treatment of symptomatic endometriosis: a before and after study.
        Fertil. Steril. 2016; 105 (e3): 734-743
        • Vercellini P.
        • Fedele L.
        • Aimi G.
        • Pietropaolo G.
        • Consonni D.
        • Crosignani P.G.
        Association between endometriosis stage, lesion type, patient characteristics and severity of pelvic pain symptoms: a multivariate analysis of over 1000 patients.
        Hum. Reprod. 2007; 22: 266-271
        • Vercellini P.
        • Somigliana E.
        • Vigano P.
        • Abbiati A.
        • Barbara G.
        • Fedele L.
        Chronic pelvic pain in women: aetiology, pathogenesis and diagnostic approach.
        Gynecol. Endocrinol. 2009; 25: 149-158
        • Von Elm E.
        • Altman D.G.
        • Egger M.
        • Pocock S.J.
        • Gøtzsche P.C.
        • Vandenbrouckef J.P.
        The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for reporting observational studies.
        Bulletin of the World Health Organization. 2007; 85: 867-872
        • Wayne P.M.
        • Kerr C.E.
        • Schnyer R.N.
        • Legedza A.T.R.
        • Savetsky-German J.
        • Shields M.H.
        • Buring J.E.
        • Davis R.B.
        • Conboy L.A.
        • Highfield E.
        • Parton B.
        • Thomas P.
        • Laufer M.R.
        Japanese-Style Acupuncture for Endometriosis-Related Pelvic Pain in Adolescents and Young Women: Results of a Randomized Sham-Controlled Trial.
        Journal of Pediatric and Adolescent Gynecology. 2008; 21: 247-257
        • White A.
        The safety of acupuncture–Evidence from the UK.
        Acupuncture in Medicine. 2006; 24: S53-S57
        • Wieser F.
        • Cohen M.
        • Gaeddert A.
        • Yu J.
        • Burks-Wicks C.
        • Berga S.L.
        • Taylor R.N.
        Evolution of medical treatment for endometriosis: Back to the roots?.
        Human Reproduction Update. 2007; 13: 487-499
        • Xia J.F.
        • Inagaki Y.
        • Zhang J.F.
        • Wang L.
        • Song P.P.
        Chinese medicine as complementary therapy for female infertility.
        Chinese Journal of Integrative Medicine. 2017; 23: 245-252
        • Xiang D.
        • Situ Y.
        • Liang X.
        • Cheng L.
        • Zhang G.
        Ear acupuncture therapy for 37 cases of dys-menorrhoea due to endometriosis.
        Journal of Traditional Chinese Medicine. 2002; 22: 282-285
        • Yin P.
        • Gao N.
        • Wu J.
        • Litscher G.
        • Xu S.
        Adverse events of massage therapy in pain-related conditions: a systematic review.
        Evid Based Complement Alternat Med. 2014; 480956
        • Zhu X.
        • Hamilton K.D.
        • McNicol E.D.
        Acupuncture for pain in endometriosis.
        Cochrane database of systematic reviews (Online). 2011; 9CD007864

      Biography

      Alexandra Sabrina Kohl Schwartz works as a Research Fellow at the University Hospital in Zurich and as a Consultant in Reproductive Medicine at the Women's University Hospital in Berne, Switzerland. Her main interests are endometriosis, implantation failure and long-term consequences of children conceived after reproductive treatment.
      Key message
      Many endometriosis-affected women use complementary health approaches or home remedies to relieve pain as they suffer from adverse effects of hormonal therapy and/or recurring pain and/or are unsatisfied with standard healthcare. Hence, to better meet the needs of patients, we recommend addressing individual treatment options in clinical practice.