Advertisement
Article| Volume 38, ISSUE 5, P835-844, May 2019

Download started.

Ok

Knowledge, attitudes and practice of physicians towards fertility and pregnancy-related issues in youngBRCA-mutated breast cancer patients

Published:January 09, 2019DOI:https://doi.org/10.1016/j.rbmo.2018.11.031
Knowledge, attitudes and practice of physicians towards fertility and pregnancy-related issues in youngBRCA-mutated breast cancer patients
Previous ArticleAbsence of predictable long-term molecular effect of ulipristal acetate (UPA) on the endometrium
Next ArticleA multicentre evaluation of the Elecsys® anti-Müllerian hormone immunoassay for prediction of antral follicle count

      Abstract

      Research question

      This study explored the knowledge, attitudes and practice of physicians towards fertility and pregnancy-related issues in young BRCA-mutated breast cancer patients.

      Design

      Physicians attending two international breast cancer conferences completed a 26-item questionnaire exploring fertility preservation, pregnancy during (BCP) or after breast cancer. A statistical comparison was carried out of the responses exploring the same issues in young breast cancer patients overall or specifically in those with BRCA mutations.

      Results

      The survey was completed by 273 physicians. Ovarian tissue cryopreservation (33% versus 40%; P = 0.009) and gonadotrophin-releasing hormone analogues during chemotherapy (74% versus 81%; P = 0.001) were less commonly suggested in BRCA-mutated patients than in the overall breast cancer population. 42% of respondents agreed or were neutral on the statement that ovarian stimulation should not be considered safe in BRCA-mutated breast cancer patients.
      45% and 30% agreed or were neutral on the statement that pregnancy in breast cancer survivors may increase the risk of recurrence in BRCA-mutated patients or in the overall breast cancer population, respectively (P < 0.001). 15% and 3% disagreed that transplanting the cryopreserved ovarian tissue can be considered safe in BRCA-mutated patients or in the overall breast cancer population, respectively (P < 0.001). 33.3% were against the addition of platinum agents as neoadjuvant chemotherapy in BRCA-mutated patients with BCP.

      Conclusions

      Several misconceptions on fertility preservation and pregnancy-related issues in breast cancer patients persist even among physicians directly involved in breast cancer care. Focused research efforts to address these issues in BRCA-mutated breast cancer patients and education to improve physicians’ knowledge and adherence to available guidelines are urgently needed.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Reproductive BioMedicine Online
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Adams E.
        • Hill E.
        • Watson E.
        Fertility preservation in cancer survivors: a national survey of oncologists’ current knowledge, practice and attitudes.
        Br. J. Cancer. 2013; 108: 1602-1615
        https://doi.org/10.1038/bjc.2013.139
        View in Article
        • Amant F.
        • Vandenbroucke T.
        • Verheecke M.
        • Fumagalli M.
        • Halaska M.J.
        • Boere I.
        • Han S.
        • Gziri M.M.
        • Peccatori F.
        • Rob L.
        • Lok C.
        • Witteveen P.
        • Voigt J.-U.
        • Naulaers G.
        • Vallaeys L.
        • Van den Heuvel F.
        • Lagae L.
        • Mertens L.
        • Claes L.
        • Van Calsteren K.
        • International Network on Cancer, Infertility, and Pregnancy (INCIP)
        Pediatric Outcome after Maternal Cancer Diagnosed during Pregnancy.
        N. Engl. J. Med. 2015; 373: 1824-1834
        https://doi.org/10.1056/NEJMoa1508913
        View in Article
        • Anderson R.A.
        • Brewster D.H.
        • Wood R.
        • Nowell S.
        • Fischbacher C.
        • Kelsey T.W.
        • Wallace W.H.B.
        The impact of cancer on subsequent chance of pregnancy: a population-based analysis.
        Hum. Reprod. 2018; 33: 1281-1290
        https://doi.org/10.1093/humrep/dey216
        View in Article
        • Biglia N.
        • Torrisi R.
        • D'Alonzo M.
        • Codacci Pisanelli G.
        • Rota S.
        • Peccatori F.A.
        Attitudes on fertility issues in breast cancer patients: an Italian survey.
        Gynecol. Endocrinol. 2015; 31: 458-464
        https://doi.org/10.3109/09513590.2014.1003293
        View in Article
        • Cardoso F.
        • Senkus E.
        • Costa A.
        • Papadopoulos E.
        • Aapro M.
        • André F.
        • Harbeck N.
        • Aguilar Lopez B.
        • Barrios C.H.
        • Bergh J.
        • Biganzoli L.
        • Boers-Doets C.B.
        • Cardoso M.J.
        • Carey L.A.
        • Cortés J.
        • Curigliano G.
        • Diéras V.
        • El Saghir N.S.
        • Eniu A.
        • Fallowfield L.
        • Francis P.A.
        • Gelmon K.
        • Johnston S.R.D.
        • Kaufman B.
        • Koppikar S.
        • Krop I.E.
        • Mayer M.
        • Nakigudde G.
        • Offersen B.V.
        • Ohno S.
        • Pagani O.
        • Paluch-Shimon S.
        • Penault-Llorca F.
        • Prat A.
        • Rugo H.S.
        • Sledge G.W.
        • Spence D.
        • Thomssen C.
        • Vorobiof D.A.
        • Xu B.
        • Norton L.
        • Winer E.P.
        4th ESO-ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 4)†.
        Ann. Oncol. 2018; 29: 1634-1657
        https://doi.org/10.1093/annonc/mdy192
        View in Article
        • Chan J.L.
        • Johnson L.N.C.
        • Sammel M.D.
        • DiGiovanni L.
        • Voong C.
        • Domchek S.M.
        • Gracia C.R.
        Reproductive Decision-Making in Women with BRCA1/2 Mutations.
        J. Genet. Couns. 2017; 26: 594-603
        https://doi.org/10.1007/s10897–016–0035-x
        View in Article
        • Cobo A.
        • García-Velasco J.
        • Domingo J.
        • Pellicer A.
        • Remohí J.
        Elective and Onco-fertility preservation: factors related to IVF outcomes.
        Hum Reprod. 2018; ([Epub ahead of print])
        https://doi.org/10.1093/humrep/dey321
        View in Article
        • Copson E.R.
        • Maishman T.C.
        • Tapper W.J.
        • Cutress R.I.
        • Greville-Heygate S.
        • Altman D.G.
        • Eccles B.
        • Gerty S.
        • Durcan L.T.
        • Jones L.
        • Evans D.G.
        • Thompson A.M.
        • Pharoah P.
        • Easton D.F.
        • Dunning A.M.
        • Hanby A.
        • Lakhani S.
        • Eeles R.
        • Gilbert F.J.
        • Hamed H.
        • Hodgson S.
        • Simmonds P.
        • Stanton L.
        • Eccles D.M.
        Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study.
        Lancet. Oncol. 2018; 19: 169-180
        https://doi.org/10.1016/S1470–2045(17)30891–4
        View in Article
        • Curigliano G.
        • Burstein H.J.
        • P Winer E.
        • Gnant M.
        • Dubsky P.
        • Loibl S.
        • Colleoni M.
        • Regan M.M.
        • Piccart-Gebhart M.
        • Senn H.-J.
        • Thürlimann B.
        • André F.
        • Baselga J.
        • Bergh J.
        • Bonnefoi H.
        • Y Brucker S.
        • Cardoso F.
        • Carey L.
        • Ciruelos E.
        • Cuzick J.
        • Denkert C.
        • Di Leo A.
        • Ejlertsen B.
        • Francis P.
        • Galimberti V.
        • Garber J.
        • Gulluoglu B.
        • Goodwin P.
        • Harbeck N.
        • Hayes D.F.
        • Huang C.-S.
        • Huober J.
        • Hussein K.
        • Jassem J.
        • Jiang Z.
        • Karlsson P.
        • Morrow M.
        • Orecchia R.
        • Osborne K.C.
        • Pagani O.
        • Partridge A.H.
        • Pritchard K.
        • Ro J.
        • Rutgers E.J.T.
        • Sedlmayer F.
        • Semiglazov V.
        • Shao Z.
        • Smith I.
        • Toi M.
        • Tutt A.
        • Viale G.
        • Watanabe T.
        • Whelan T.J.
        • Xu B.
        • St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2017
        De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017.
        Ann. Oncol. 2017; 28: 1700-1712
        https://doi.org/10.1093/annonc/mdx308
        View in Article
        • de Haan J.
        • Verheecke M.
        • Van Calsteren K.
        • Van Calster B.
        • Shmakov R.G.
        • Mhallem Gziri M.
        • Halaska M.J.
        • Fruscio R.
        • Lok C.A.R.
        • Boere I.A.
        • Zola P.
        • Ottevanger P.B.
        • de Groot C.J.M.
        • Peccatori F.A.
        • Dahl Steffensen K.
        • Cardonick E.H.
        • Polushkina E.
        • Rob L.
        • Ceppi L.
        • Sukhikh G.T.
        • Han S.N.
        • Amant F.
        • International Network on Cancer and Infertility Pregnancy (INCIP)
        Oncological management and obstetric and neonatal outcomes for women diagnosed with cancer during pregnancy: a 20-year international cohort study of 1170 patients.
        Lancet Oncol. 2018; 19: 337-346
        https://doi.org/10.1016/S1470–2045(18)30059–7
        View in Article
        • Forman E.J.
        • Anders C.K.
        • Behera M.A.
        A nationwide survey of oncologists regarding treatment-related infertility and fertility preservation in female cancer patients.
        Fertil. Steril. 2010; 94: 1652-1656
        https://doi.org/10.1016/j.fertnstert.2009.10.008
        View in Article
        • Gietel-Habets J.J.G.
        • de Die-Smulders C.E.M.
        • Derks-Smeets I.a.P.
        • Tibben A.
        • Tjan-Heijnen V.C.G.
        • van Golde R.
        • Gomez-Garcia E.
        • Kets C.M.
        • van Osch L.a.D.M.
        Awareness and attitude regarding reproductive options of persons carrying a BRCA mutation and their partners.
        Hum. Reprod. 2017; 32: 588-597
        https://doi.org/10.1093/humrep/dew352
        View in Article
        • Gietel-Habets J.J.G.
        • de Die-Smulders C.E.M.
        • Tjan-Heijnen V.C.G.
        • Derks-Smeets I.a.P.
        • van Golde R.
        • Gomez-Garcia E.
        • van Osch L.a.D.M.
        Professionals’ knowledge, attitude and referral behaviour of preimplantation genetic diagnosis for hereditary breast and ovarian cancer.
        Reprod. Biomed. Online. 2018; 36: 137-144
        https://doi.org/10.1016/j.rbmo.2017.11.005
        View in Article
        • Goldrat O.
        • Kroman N.
        • Peccatori F.A.
        • Cordoba O.
        • Pistilli B.
        • Lidegaard O.
        • Demeestere I.
        • Azim H.A.
        Pregnancy following breast cancer using assisted reproduction and its effect on long-term outcome.
        Eur. J. Cancer. 2015; 51: 1490-1496
        https://doi.org/10.1016/j.ejca.2015.05.007
        View in Article
        • Hartman E.K.
        • Eslick G.D.
        The prognosis of women diagnosed with breast cancer before, during and after pregnancy: a meta-analysis.
        Breast. Cancer. Res. Treat. 2016; 160: 347-360
        https://doi.org/10.1007/s10549–016–3989–3
        View in Article
        • Iqbal J.
        • Amir E.
        • Rochon P.A.
        • Giannakeas V.
        • Sun P.
        • Narod S.A.
        Association of the Timing of Pregnancy with Survival in Women With Breast Cancer.
        JAMA. Oncol. 2017; 3: 659-665
        https://doi.org/10.1001/jamaoncol.2017.0248
        View in Article
        • Jensen A.K.
        • Macklon K.T.
        • Fedder J.
        • Ernst E.
        • Humaidan P.
        • Andersen C.Y.
        86 successful births and 9 ongoing pregnancies worldwide in women transplanted with frozen-thawed ovarian tissue: focus on birth and perinatal outcome in 40 of these children.
        J. Assist. Reprod. Genet. 2017; 34: 325-336
        https://doi.org/10.1007/s10815–016–0843–9
        View in Article
        • Kim J.
        • Turan V.
        • Oktay K.
        Long-Term Safety of Letrozole and Gonadotrophin Stimulation for Fertility Preservation in Women with Breast Cancer.
        J. Clin. Endocrinol. Metab. 2016; 101: 1364-1371
        https://doi.org/10.1210/jc.2015–3878
        View in Article
        • Kuchenbaecker K.B.
        • Hopper J.L.
        • Barnes D.R.
        • Phillips K.-A.
        • Mooij T.M.
        • Roos-Blom M.-J.
        • Jervis S.
        • van Leeuwen F.E.
        • Milne R.L.
        • Andrieu N.
        • Goldgar D.E.
        • Terry M.B.
        • Rookus M.A.
        • Easton D.F.
        • Antoniou A.C.
        • McGuffog L.
        • Evans D.G.
        • Barrowdale D.
        • Frost D.
        • Adlard J.
        • Ong K.-R.
        • Izatt L.
        • Tischkowitz M.
        • Eeles R.
        • Davidson R.
        • Hodgson S.
        • Ellis S.
        • Nogues C.
        • Lasset C.
        • Stoppa-Lyonnet D.
        • Fricker J.-P.
        • Faivre L.
        • Berthet P.
        • Hooning M.J.
        • van der Kolk L.E.
        • Kets C.M.
        • Adank M.A.
        • John E.M.
        • Chung W.K.
        • Andrulis I.L.
        • Southey M.
        • Daly M.B.
        • Buys S.S.
        • Osorio A.
        • Engel C.
        • Kast K.
        • Schmutzler R.K.
        • Caldes T.
        • Jakubowska A.
        • Simard J.
        • Friedlander M.L.
        • McLachlan S.-A.
        • Machackova E.
        • Foretova L.
        • Tan Y.Y.
        • Singer C.F.
        • Olah E.
        • Gerdes A.-M.
        • Arver B.
        • Olsson H.
        • BRCA1 and BRCA2 Cohort Consortium, null
        Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers.
        JAMA. 2017; 317: 2402-2416
        https://doi.org/10.1001/jama.2017.7112
        View in Article
        • Lambertini M.
        • Ceppi M.
        • Poggio F.
        • Peccatori F.A.
        • Azim H.A.
        • Ugolini D.
        • Pronzato P.
        • Loibl S.
        • Moore H.C.F.
        • Partridge A.H.
        • Bruzzi P.
        • Del Mastro L.
        Ovarian suppression using luteinizing hormone-releasing hormone agonists during chemotherapy to preserve ovarian function and fertility of breast cancer patients: a meta-analysis of randomized studies.
        Ann. Oncol. 2015; 26: 2408-2419
        https://doi.org/10.1093/annonc/mdv374
        View in Article
        • Lambertini M.
        • Cinquini M.
        • Moschetti I.
        • Peccatori F.A.
        • Anserini P.
        • Valenzano Menada M.
        • Tomirotti M.
        • Del Mastro L.
        Temporary ovarian suppression during chemotherapy to preserve ovarian function and fertility in breast cancer patients: A GRADE approach for evidence evaluation and recommendations by the Italian Association of Medical Oncology.
        Eur. J. Cancer. 2017; 71: 25-33
        https://doi.org/10.1016/j.ejca.2016.10.034
        View in Article
        • Lambertini M.
        • Del Mastro L.
        • Pescio M.C.
        • Andersen C.Y.
        • Azim H.A.
        • Peccatori F.A.
        • Costa M.
        • Revelli A.
        • Salvagno F.
        • Gennari A.
        • Ubaldi F.M.
        • La Sala G.B.
        • De Stefano C.
        • Wallace W.H.
        • Partridge A.H.
        • Anserini P.
        Cancer and fertility preservation: international recommendations from an expert meeting.
        BMC. Med. 2016; 14: 1
        https://doi.org/10.1186/s12916–015–0545–7
        View in Article
        • Lambertini Matteo
        • Di Maio M.
        • Pagani O.
        • Curigliano G.
        • Poggio F.
        • Del Mastro L.
        • Paluch-Shimon S.
        • Loibl S.
        • Partridge A.H.
        • Demeestere I.
        • Azim H.A.
        • Peccatori F.A.
        The BCY3/BCC 2017 survey on physicians’ knowledge, attitudes and practice towards fertility and pregnancy-related issues in young breast cancer patients.
        Breast. 2018; 42: 41-49
        https://doi.org/10.1016/j.breast.2018.08.099
        View in Article
        • Lambertini M.
        • Fontanella C.
        How reliable are the available safety data on hormonal stimulation for fertility preservation in young women with newly diagnosed early breast cancer?.
        Breast. Cancer. Res. Treat. 2018; 168: 773-774
        https://doi.org/10.1007/s10549–017–4654–1
        View in Article
        • Lambertini M.
        • Goldrat O.
        • Ferreira A.R.
        • Dechene J.
        • Azim H.A.
        • Desir J.
        • Delbaere A.
        • t'Kint de Roodenbeke M.-D.
        • de Azambuja E.
        • Ignatiadis M.
        • Demeestere I.
        Reproductive potential and performance of fertility preservation strategies in BRCA-mutated breast cancer patients.
        Ann. Oncol. 2018; 29: 237-243
        https://doi.org/10.1093/annonc/mdx639
        View in Article
        • Lambertini M.
        • Goldrat O.
        • Toss A.
        • Azim H.A.
        • Peccatori F.A.
        • Ignatiadis M.
        • Del Mastro L.
        • Demeestere I.
        Fertility and pregnancy issues in BRCA-mutated breast cancer patients.
        Cancer. Treat. Rev. 2017; 59: 61-70
        https://doi.org/10.1016/j.ctrv.2017.07.001
        View in Article
        • Lambertini Matteo
        • Kroman N.
        • Ameye L.
        • Cordoba O.
        • Pinto A.
        • Benedetti G.
        • Jensen M.-B.
        • Gelber S.
        • Del Grande M.
        • Ignatiadis M.
        • de Azambuja E.
        • Paesmans M.
        • Peccatori F.A.
        • Azim H.A.
        Long-term Safety of Pregnancy Following Breast Cancer According to oestrogen Receptor Status.
        J. Natl. Cancer. Inst. 2018; 110: 426-429
        https://doi.org/10.1093/jnci/djx206
        View in Article
        • Lambertini M.
        • Martel S.
        • Campbell C.
        • Guillaume S.
        • Hilbers F.S.
        • Schuehly U.
        • Korde L.
        • Azim Jr., H.A.
        • Di Cosimo S.
        • Tenglin R.C.
        • Huober J.
        • Baselga J.
        • Moreno-Aspitia A.
        • Piccart-Gebhart M.
        • Gelber R.D.
        • de Azambuja E.
        • Ignatiadis M.
        Pregnancies during and after trastuzumab and/or lapatinib in patients with human epidermal growth factor receptor 2-positive early breast cancer: analysis from the NeoALTTO (BIG 1–06) and ALTTO (BIG 2–06) trials.
        Cancer. 2019; 125: 307-316
        https://doi.org/10.1002/cncr.31784
        View in Article
        • Lambertini Matteo
        • Moore H.C.F.
        • Leonard R.C.F.
        • Loibl S.
        • Munster P.
        • Bruzzone M.
        • Boni L.
        • Unger J.M.
        • Anderson R.A.
        • Mehta K.
        • Minton S.
        • Poggio F.
        • Albain K.S.
        • Adamson D.J.A.
        • Gerber B.
        • Cripps A.
        • Bertelli G.
        • Seiler S.
        • Ceppi M.
        • Partridge A.H.
        • Del Mastro L.
        Gonadotrophin-Releasing Hormone Agonists During Chemotherapy for Preservation of Ovarian Function and Fertility in Premenopausal Patients With Early Breast Cancer: A Systematic Review and Meta-Analysis of Individual Patient-Level Data.
        J. Clin. Oncol. 2018; 36: 1981-1990
        https://doi.org/10.1200/JCO.2018.78.0858
        View in Article
        • Letourneau J.M.
        • Ebbel E.E.
        • Katz P.P.
        • Katz A.
        • Ai W.Z.
        • Chien A.J.
        • Melisko M.E.
        • Cedars M.I.
        • Rosen M.P.
        Pretreatment fertility counselling and fertility preservation improve quality of life in reproductive age women with cancer.
        Cancer. 2012; 118: 1710-1717
        https://doi.org/10.1002/cncr.26459
        View in Article
        • Loibl S.
        • Han S.N.
        • von Minckwitz G.
        • Bontenbal M.
        • Ring A.
        • Giermek J.
        • Fehm T.
        • Van Calsteren K.
        • Linn S.C.
        • Schlehe B.
        • Gziri M.M.
        • Westenend P.J.
        • Müller V.
        • Heyns L.
        • Rack B.
        • Van Calster B.
        • Harbeck N.
        • Lenhard M.
        • Halaska M.J.
        • Kaufmann M.
        • Nekljudova V.
        • Amant F.
        Treatment of breast cancer during pregnancy: an observational study.
        Lancet. Oncol. 2012; 13: 887-896
        https://doi.org/10.1016/S1470–2045(12)70261–9
        View in Article
        • Loibl S.
        • Schmidt A.
        • Gentilini O.
        • Kaufman B.
        • Kuhl C.
        • Denkert C.
        • von Minckwitz G.
        • Parokonnaya A.
        • Stensheim H.
        • Thomssen C.
        • van Calsteren K.
        • Poortmans P.
        • Berveiller P.
        • Markert U.R.
        • Amant F.
        Breast Cancer Diagnosed During Pregnancy: Adapting Recent Advances in Breast Cancer Care for Pregnant Patients.
        JAMA. Oncol. 2015; 1: 1145-1153
        https://doi.org/10.1001/jamaoncol.2015.2413
        View in Article
        • Massarotti C.
        • Scaruffi P.
        • Lambertini M.
        • Remorgida V.
        • Del Mastro L.
        • Anserini P.
        State of the art on oocyte cryopreservation in female cancer patients: A critical review of the literature.
        Cancer. Treat. Rev. 2017; 57: 50-57
        https://doi.org/10.1016/j.ctrv.2017.04.009
        View in Article
        • Oktay K.
        • Harvey B.E.
        • Partridge A.H.
        • Quinn G.P.
        • Reinecke J.
        • Taylor H.S.
        • Wallace W.H.
        • Wang E.T.
        • Loren A.W.
        Fertility Preservation in Patients with Cancer: ASCO Clinical Practice Guideline Update.
        J. Clin. Oncol. 2018; 36: 1994-2001
        https://doi.org/10.1200/JCO.2018.78.1914
        View in Article
        • Oktay K.
        • Turan V.
        • Bedoschi G.
        • Pacheco F.S.
        • Moy F.
        Fertility Preservation Success Subsequent to Concurrent Aromatase Inhibitor Treatment and Ovarian Stimulation in Women with Breast Cancer.
        J. Clin. Oncol. 2015; 33: 2424-2429
        https://doi.org/10.1200/JCO.2014.59.3723
        View in Article
        • Pacheco F.
        • Oktay K.
        Current Success and Efficiency of Autologous Ovarian Transplantation: A Meta-Analysis.
        Reprod. Sci. 2017; 24: 1111-1120
        https://doi.org/10.1177/1933719117702251
        View in Article
        • Pagani O
        • Bagnardi V
        • Ruggeri M
        • Bianco N
        • Gallerani E
        • Buser K
        • Giordano M
        • Gianni L
        • Rabaglio M
        • Freschi A
        • Cretella E
        • Clerico M
        • Amadori D
        • Simoncini E
        • Ciccarese M
        • Rauch D
        • Rosti G
        • Glaus A
        • Berardi R
        • Franzetti Pellanda A
        • Ruddy KJ
        • Gelber S
        • Partridge AH
        • Colleoni M
        HOHO Study (IBCSG 43–09): how European and US young women cope with breast cancer and fertility concerns.
        Cancer. Res. 2017; 77 (abstract PD6–04-PD6–04)
        View in Article
        • Pagani O.
        • Ruggeri M.
        • Manunta S.
        • Saunders C.
        • Peccatori F.
        • Cardoso F.
        • Kaufman B.
        • Paluch-Shimon S.
        • Gewefel H.
        • Gallerani E.
        • Abulkhair O.M.
        • Pistilli B.
        • Warner E.
        • Saloustros E.
        • Perey L.
        • Zaman K.
        • Rabaglio M.
        • Gelber S.
        • Gelber R.D.
        • Goldhirsch A.
        • Korde L.
        • Azim H.A.
        • Partridge A.H.
        Pregnancy after breast cancer: Are young patients willing to participate in clinical studies?.
        Breast. 2015; 24: 201-207
        https://doi.org/10.1016/j.breast.2015.01.005
        View in Article
        • Paluch-Shimon S.
        • Cardoso F.
        • Sessa C.
        • Balmana J.
        • Cardoso M.J.
        • Gilbert F.
        • Senkus E.
        • ESMO Guidelines Committee
        Prevention and screening in BRCA mutation carriers and other breast/ovarian hereditary cancer syndromes: ESMO Clinical Practice Guidelines for cancer prevention and screening.
        Ann. Oncol. 2016; 27: v103-v110
        https://doi.org/10.1093/annonc/mdw327
        View in Article
        • Paluch-Shimon S.
        • Pagani O.
        • Partridge A.H.
        • Abulkhair O.
        • Cardoso M.-J.
        • Dent R.A.
        • Gelmon K.
        • Gentilini O.
        • Harbeck N.
        • Margulies A.
        • Meirow D.
        • Pruneri G.
        • Senkus E.
        • Spanic T.
        • Sutliff M.
        • Travado L.
        • Peccatori F.
        • Cardoso F.
        ESO-ESMO 3rd international consensus guidelines for breast cancer in young women (BCY3).
        Breast. 2017; 35: 203-217
        https://doi.org/10.1016/j.breast.2017.07.017
        View in Article
        • Peccatori F.A.
        • Azim Jr., H.A.
        • Orecchia R.
        • Hoekstra H.J.
        • Pavlidis N.
        • Kesic V.
        • Pentheroudakis G.
        • ESMO Guidelines Working Group
        Cancer, pregnancy and fertility: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
        Ann. Oncol. 2013; 24: vi160-vi170
        https://doi.org/10.1093/annonc/mdt199
        View in Article
        • Poggio F.
        • Bruzzone M.
        • Ceppi M.
        • Pondé N.F.
        • La Valle G.
        • Del Mastro L.
        • de Azambuja E.
        • Lambertini M.
        Platinum-based neoadjuvant chemotherapy in triple-negative breast cancer: a systematic review and meta-analysis.
        Ann. Oncol. 2018; 29: 1497-1508
        https://doi.org/10.1093/annonc/mdy127
        View in Article
        • Quinn G.P.
        • Vadaparampil S.T.
        • Lee J.-H.
        • Jacobsen P.B.
        • Bepler G.
        • Lancaster J.
        • Keefe D.L.
        • Albrecht T.L.
        Physician referral for fertility preservation in oncology patients: a national study of practice behaviours.
        J. Clin. Oncol. 2009; 27: 5952-5957
        https://doi.org/10.1200/JCO.2009.23.0250
        View in Article
        • Rodriguez-Wallberg K.A.
        • Eloranta S.
        • Krawiec K.
        • Lissmats A.
        • Bergh J.
        • Liljegren A.
        Safety of fertility preservation in breast cancer patients in a register-based matched cohort study.
        Breast. Cancer. Res. Treat. 2018; 167: 761-769
        https://doi.org/10.1007/s10549–017–4555–3
        View in Article
        • Rosenberg S.M.
        • Ruddy K.J.
        • Tamimi R.M.
        • Gelber S.
        • Schapira L.
        • Come S.
        • Borges V.F.
        • Larsen B.
        • Garber J.E.
        • Partridge A.H.
        BRCA1 and BRCA2 Mutation Testing in Young Women with Breast Cancer.
        JAMA. Oncol. 2016; 2: 730-736
        https://doi.org/10.1001/jamaoncol.2015.5941
        View in Article
        • Ruddy K.J.
        • Gelber S.I.
        • Tamimi R.M.
        • Ginsburg E.S.
        • Schapira L.
        • Come S.E.
        • Borges V.F.
        • Meyer M.E.
        • Partridge A.H.
        Prospective study of fertility concerns and preservation strategies in young women with breast cancer.
        J. Clin. Oncol. 2014; 32: 1151-1156
        https://doi.org/10.1200/JCO.2013.52.8877
        View in Article
        • Senkus E.
        • Gomez H.
        • Dirix L.
        • Jerusalem G.
        • Murray E.
        • Van Tienhoven G.
        • Westenberg A.H.
        • Bottomley A.
        • Rapion J.
        • Bogaerts J.
        • Di Leo A.
        • Nešković-Konstantinović Z.
        Attitudes of young patients with breast cancer toward fertility loss related to adjuvant systemic therapies. EORTC study 10002 BIG 3–98.
        Psychooncology. 2014; 23: 173-182
        https://doi.org/10.1002/pon.3384
        View in Article
        • Shapira M.
        • Raanani H.
        • Feldman B.
        • Srebnik N.
        • Dereck-Haim S.
        • Manela D.
        • Brenghausen M.
        • Geva-Lerner L.
        • Friedman E.
        • Levi-Lahad E.
        • Goldberg D.
        • Perri T.
        • Eldar-Geva T.
        • Meirow D.
        BRCA mutation carriers show normal ovarian response inin vitro fertilization cycles.
        Fertil. Steril. 2015; 104: 1162-1167
        https://doi.org/10.1016/j.fertnstert.2015.07.1162
        View in Article
        • Turan V.
        • Bedoschi G.
        • Emirdar V.
        • Moy F.
        • Oktay K.
        Ovarian Stimulation in Patients with Cancer: Impact of Letrozole and BRCA Mutations on Fertility Preservation Cycle Outcomes.
        Reprod. Sci. 2018; 25: 26-32
        https://doi.org/10.1177/1933719117728800
        View in Article
        • Valentini A.
        • Lubinski J.
        • Byrski T.
        • Ghadirian P.
        • Moller P.
        • Lynch H.T.
        • Ainsworth P.
        • Neuhausen S.L.
        • Weitzel J.
        • Singer C.F.
        • Olopade O.I.
        • Saal H.
        • Lyonnet D.S.
        • Foulkes W.D.
        • Kim-Sing C.
        • Manoukian S.
        • Zakalik D.
        • Armel S.
        • Senter L.
        • Eng C.
        • Grunfeld E.
        • Chiarelli A.M.
        • Poll A.
        • Sun P.
        • Narod S.A.
        • Hereditary Breast Cancer Clinical Study Group
        The impact of pregnancy on breast cancer survival in women who carry a BRCA1 or BRCA2 mutation.
        Breast. Cancer. Res. Treat. 2013; 142: 177-185
        https://doi.org/10.1007/s10549–013–2729–1
        View in Article
        • Woodson A.H.
        • Muse K.I.
        • Lin H.
        • Jackson M.
        • Mattair D.N.
        • Schover L.
        • Woodard T.
        • McKenzie L.
        • Theriault R.L.
        • Hortobágyi G.N.
        • Arun B.
        • Peterson S.K.
        • Profato J.
        • Litton J.K.
        Breast cancer, BRCA mutations, and attitudes regarding pregnancy and preimplantation genetic diagnosis.
        The Oncologist. 2014; 19: 797-804
        https://doi.org/10.1634/theoncologist.2014–0057
        View in Article

      Biography

      Matteo Lambertini is adjunct professor and consultant in medical oncology at the IRCCS Ospedale Policlinico San Martino - University of Genova in Genova, Italy, with a particular expertise in the management of breast cancer in young women. He has authored several publications in peer-reviewed journals and book chapters on this topic.
      Key message
      This survey exploring physicians’ perspectives towards fertility and pregnancy-related issues in young BRCA-mutated breast cancer patients showed that several misconceptions on these topics persist even among professionals directly involved in breast cancer care. Focused research efforts in BRCA-mutated patients and education to improve physicians’ adherence to guidelines are needed.

      Article info

      Publication history

      Published online: January 09, 2019
      Accepted: November 27, 2018
      Received in revised form: November 13, 2018
      Received: October 10, 2018
      Declaration: Matteo Lambertini served as a consultant for Teva and received speaker honoraria from Theramex outside the submitted work. Hatem A Azim Jr. reports employment at Innate Pharma at the end of this study; this employment is not related in any way to the subject of the current study. All remaining authors declare no conflict of interest.

      Identification

      DOI: https://doi.org/10.1016/j.rbmo.2018.11.031

      Copyright

      © 2019 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

      ScienceDirect

      Access this article on ScienceDirect

      The content on this site is intended for healthcare professionals.


      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the Cookie Preference Center for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties.


      RELX