Abstract
Research question
Can serum kisspeptin levels 14 and 21 days after frozen–thawed embryo transfer predict
the early pregnancy outcome of patients?
Design
Prospective study, with 133 patients undergoing frozen–thawed embryo transfer. Patients
were divided into non-pregnant group and pregnant group (including biochemical pregnancy,
singleton pregnancy, miscarriage and twin groups).
Results
Serum kisspeptin levels on day 21 were significantly higher than day 14 in singleton
pregnancy, miscarriage and twin groups (all P < 0.0001), but not in the biochemical pregnancy group. Similarly, serum human chorionic
gonadotrophin (HCG) levels were higher on day 21 compared with day 14 except for the
biochemical pregnancy group. Compared with the twin group (296.9 pg/ml), the other
four groups showed significantly higher serum kisspeptin levels on day 14 (non-pregnant
548.9, biochemical pregnancy 440.4, miscarriage 434.9, singleton pregnancy group 420.9 pg/ml,
P < 0.01, P = 0.016, P = 0.034, P = 0.036, respectively). The miscarriage (762.2 pg/ml), singleton pregnancy (730.8 pg/ml)
and twin groups (826.3 pg/ml) had significantly higher kisspeptin levels than the
biochemical pregnancy group (397.3 pg/ml) on day 21 (P < 0.001, P < 0.01, P < 0.001, respectively). Serum kisspeptin levels on day 14 were negatively correlated
with embryo implantation rate (P = 0.035, R2 = –0.880). Serum kisspeptin levels on day 21 have a poor predictive value of miscarriage
compared with serum HCG levels (area under the curve = 0.53 and 0.78, respectively).
Conclusions
Serum kisspeptin levels on day 14 are negatively correlated with embryo implantation
rate. Serum kisspeptin levels on day 21 have a poor predictive value of miscarriage.
Keywords
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Biography
Kai-Lun Hu is a graduate student at Peking University. He concluded his medical research at the Peking University Third Hospital in 2016. He earned several honours at Peking University, and has already had several scientific papers published in peer-reviewed journals.Article info
Publication history
Published online: March 12, 2019
Accepted:
March 8,
2019
Received in revised form:
February 18,
2019
Received:
December 21,
2018
Declaration: The authors report no financial or commercial conflicts of interest.Identification
Copyright
© 2019 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
