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Blastocyst euploidy rates in low-prognosis patients according to the POSEIDON criteria: a retrospective analysis of 3016 embryos

  • Author Footnotes
    # These authors contributed equally to this article.
    Mingyue Luo
    Footnotes
    # These authors contributed equally to this article.
    Affiliations
    Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan Shandong, China

    Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan Shandong, China

    Shandong Key Laboratory of Reproductive Medicine, Jinan Shandong, China

    Shandong Provincial Clinical Research Center for Reproductive Health, Jinan Shandong, China

    National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan Shandong, China
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  • Author Footnotes
    # These authors contributed equally to this article.
    Duan Li
    Footnotes
    # These authors contributed equally to this article.
    Affiliations
    Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan Shandong, China

    Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan Shandong, China

    Shandong Key Laboratory of Reproductive Medicine, Jinan Shandong, China

    Shandong Provincial Clinical Research Center for Reproductive Health, Jinan Shandong, China

    National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan Shandong, China
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  • Mingdi Xia
    Affiliations
    Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan Shandong, China

    Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan Shandong, China

    Shandong Key Laboratory of Reproductive Medicine, Jinan Shandong, China

    Shandong Provincial Clinical Research Center for Reproductive Health, Jinan Shandong, China

    National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan Shandong, China
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  • Hongqiang Xie
    Affiliations
    Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan Shandong, China

    Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan Shandong, China

    Shandong Key Laboratory of Reproductive Medicine, Jinan Shandong, China

    Shandong Provincial Clinical Research Center for Reproductive Health, Jinan Shandong, China

    National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan Shandong, China
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  • Peihao Liu
    Correspondence
    Corresponding authors.
    Affiliations
    Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan Shandong, China

    Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan Shandong, China

    Shandong Key Laboratory of Reproductive Medicine, Jinan Shandong, China

    Shandong Provincial Clinical Research Center for Reproductive Health, Jinan Shandong, China

    National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan Shandong, China
    Search for articles by this author
  • Yingying Qin
    Correspondence
    Corresponding authors.
    Affiliations
    Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan Shandong, China

    Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan Shandong, China

    Shandong Key Laboratory of Reproductive Medicine, Jinan Shandong, China

    Shandong Provincial Clinical Research Center for Reproductive Health, Jinan Shandong, China

    National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan Shandong, China
    Search for articles by this author
  • Author Footnotes
    # These authors contributed equally to this article.
Published:September 20, 2021DOI:https://doi.org/10.1016/j.rbmo.2021.09.006

      Abstract

      Research Question

      Do embryo euploidy rates differ in the four groups of women with low prognosis as stratified by the POSEIDON criteria?

      Design

      This was a retrospective cohort study of low-prognosis patients who met the POSEIDON criteria and underwent preimplantation genetic testing for aneuploidies (PGT-A) from January 2013 to June 2020 at the Center for Reproductive Medicine, Shandong University, China. A total of 3016 blastocysts from 1269 PGT-A cycles were included in the study. The primary outcome was the euploidy rate of the blastocysts. For each group, regression analyses were performed to quantitatively describe the relationship between maternal age and embryo euploidy rate.

      Results

      The euploidy rate of embryos in women with poor ovarian response (POR) was 39.1% in total. There were 727, 1052, 275 and 962 blastocysts in groups 1, 2, 3 and 4, respectively, with corresponding embryo euploidy rates of 57.2%, 34.9%, 52.4% and 26.2% (P < 0.001). Within each group, the euploidy rate decreased with age, especially in women aged 35 years or older (i.e. groups 2 and 4).

      Conclusions

      Euploidy rates were more favourable in groups 1 and 3, of a young age, re-emphasizing that oocyte quality is the primary factor determining embryo euploidy rate. The study's findings demonstrated the reasonability of categorizing women with POR by the POSEIDON criteria depending on female age and ovarian reserve biomarkers. These results also provide information for women with POR in different subgroups so they can receive proper counselling on the possible prognosis.

      Key word

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      Biography

      Mingyue Luo is pursuing her Master's degree at the Center for Reproductive Medicine of Shandong University, China. Her interests included reproductive endocrinology, embryo cryopreservation and premature ovarian insufficiency.
      Key message
      Euploidy rates varied among the four POSEIDON groups, with the highest rates in the two younger age groups (groups 1 and 3). Categorization of patients with poor ovarian response (POR) by POSEIDON criteria appears reasonable. Different euploidy rates in the POR groups provide useful information for counselling patients.