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Associations between ambient air pollution and IVF outcomes in a heavily polluted city in China

Published:October 07, 2021DOI:https://doi.org/10.1016/j.rbmo.2021.09.026

      Abstract

      Research question

      Is air pollution related to IVF outcomes in a heavily polluted city in China?

      Design

      A retrospective cohort study of 8628 fresh, autologous IVF cycles was conducted for the first time at the Reproductive Medicine Center of The Third Affiliated Hospital of Zhengzhou University between May 2014 and December 2018 (oocyte retrieval date). The exposure was divided into four periods (gonadotrophin injection to oocyte retrieval [P1], oocyte retrieval to embryo transfer [P2], 1 day after embryo transfer to embryo transfer +14 days [P3] and gonadotrophin injection to embryo transfer +14 days [P4]) and four levels (Q1–Q4 according to their 25th, 50th and 75th percentiles).

      Results

      An interquartile range increase (Q2 versus Q1) in particulate matter ≤10 µm (PM10) during P3 and P4 and sulphur dioxide (SO2) during P3 significantly decreased the clinical pregnancy rate (adjusted odds ratio [aOR] 0.81, 95% confidence interval [CI] 0.71–0.92 for PM10 of P3; aOR 0.87, 95% CI 0.76–1.00 for PM10 of P4; aOR 0.82, 95% CI 0.73–0.93 for SO2 of P3). In addition, PM10 was associated with an increased biochemical pregnancy rate (Q3 versus Q1: aOR 1.55, 95% CI 1.09–2.19 for PM10 of P1) and decreased live birth rate (Q2 versus Q1: aOR 0.88, 95% CI 0.77–0.99 for PM10 of P3). The multivariate regression results were consistent with that of multiple treatments propensity score method (PSM) for SO2 pollutants in P3 and PM10 pollutants in P4.

      Conclusion

      From the early follicular stage to the pregnancy test period, high concentrations of PM10 and SO2 may have a negative impact on IVF treatment outcomes in the study area.

      Keywords

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      Biography

      Jing Liu is a Doctor of Medicine, Associate Chief Physician, Associate Professor and a Master's Tutor who graduated from Xiangya Medical College of Central South University. Engaged in the field of assisted reproductive technology for 13 years, her main research interests are embryo laboratory quality control management and preimplantation genetic testing.
      Key message
      During IVF treatment, increased PM10 concentrations were associated with increased biochemical pregnancy during ovarian stimulation and reduced CPR and LBR during the post-transfer phase. For SO2, only increased concentrations during the post-transfer phase were associated with reduced CPR.