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Analysis of clinical outcomes of frozen-thawed embryos transfer after IVF/ICSI at high altitude (3,650 metres) in Tibet

  • Bin Wu
    Affiliations
    Center for Reproductive Medicine, Department of Gynecology and Obstetrics, the Affiliated Hospital of North Sichuan Medical college, Nanchong, Sichuan, China
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  • Xiang-Qian Meng
    Affiliations
    Center for Reproductive Medicine, Chengdu Jinjiang Hospital for Maternal & Child Health Care, Chengdu, Sichuan, China
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  • Jun Li
    Affiliations
    Center for Reproductive Medicine, Xizang Fukang Hospital, Lhasa, Tibet, China
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  • Gang Tang
    Correspondence
    Gang Tang, Center for Reproductive Medicine, Xizang Fukang Hospital, Lhasa, Tibet Autonomous Region, China.
    Affiliations
    Center for Reproductive Medicine, Xizang Fukang Hospital, Lhasa, Tibet, China
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  • Hong-Gui Zhou
    Correspondence
    Correspondence. Hong-Gui Zhou, Center for Reproductive Medicine, Department of Gynecology and Obstetrics, the Affiliated Hospital of North Sichuan Medical College, No. 1, Maoyuan South Road, Nanchong, Sichuan province, China.
    Affiliations
    Center for Reproductive Medicine, Department of Gynecology and Obstetrics, the Affiliated Hospital of North Sichuan Medical college, Nanchong, Sichuan, China
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Published:October 23, 2021DOI:https://doi.org/10.1016/j.rbmo.2021.10.013

      Abstract

      Research Question

      To analyze the pregnancy outcomes of in vitro fertilization frozen-thawed embryo transfer (IVF-FET) performed in a clinical setting located at an altitude of 3,650 metres in Tibet, China.

      Design

      This was a retrospective analysis of 238 infertility patients (344 treatment cycles) who underwent FET treatment at the Center for Reproductive Medicine, Xizang Fukang Hospital, Tibet. The overall clinical pregnancy rate, implantation rate, live birth rate, abortion rate and ectopic pregnancy rate were statistically analyzed. Women were categorized into two groups based on age: ≤35 years group (n=265) and >35 years group (n=79). The general characteristics and pregnancy outcomes were compared between the two groups.

      Results

      The clinical pregnancy rate, implantation rate, live birth rate, abortion rate, and ectopic pregnancy rate of the 344 FET cycles were 43.02%, 30.90%, 35.17%, 18.24%, and 1.35%, respectively. The clinical pregnancy rate (46.04% vs. 32.91%), implantation rate (33.92% vs. 21.01%), and live birth rate (38.11% vs. 25.32%) in the ≤35 years group were significantly greater than those in the >35 years group (P<0.05). The abortion rate (17.21% vs. 23.08%) and ectopic pregnancy rate (0.82% vs. 3.85%) were comparable in the two groups (P>0.05).

      Conclusion

      Good pregnancy outcomes can be achieved with IVF-FET in high-altitude areas (3,650 metres above sea level). Maternal age is still an important determinant of clinical pregnancy rate, implantation rate, and live birth rate of infertile patients in high-altitude areas.

      Keywords

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      Biography

      Bin Wu has an MSc in Physiology and has been working as a Clinical Embryologist at the Center for Reproductive Medicine, Department of Gynecology and Obstetrics, the Affiliated Hospital of North Sichuan Medical college, China. His main research interests are cryopreservation of gametes and culture of human embryos.
      Key Message
      Good pregnancy outcomes can be achieved with IVF-FET in high-altitude areas. Maternal age is still an important determinant of clinical pregnancy rate, implantation rate, and live birth rate of infertile patients in high-altitude areas.