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Are the clinical outcomes different in day 5 versus day 6 single embryo transfer when endometrial factor is controlled?

  • Tiffany Stankewicz
    Correspondence
    Corresponding author: Tiffany Stankewicz, Senior Scientific Advisor and Endometrial Specialist Igenomix, US
    Affiliations
    Igenomix SL, New York, 30 Montgomery Street, Suite 270, Jersey City, New Jersey, 07302 USA

    School of Bioscience, University of Kent, Canterbury CT2 7NJ, United Kingdom
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  • Maria Ruiz-Alonso
    Affiliations
    Igenomix R&D, Parque Tecnológico de Paterna, Ronda Narciso Monturiol Estarriol 11B, Paterna Valencia 46980, Spain
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  • Marc Soler-Ibañez
    Affiliations
    Igenomix Medical Area, Parque Tecnológico de Paterna, Ronda Narciso Monturiol Estarriol 11B, Paterna Valencia 46980, Spain
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  • Carlos Simón
    Affiliations
    Igenomix Foundation, INCLIVA Health Research Institute, Parque Tecnológico de Paterna, Ronda Narciso Monturiol Estarriol 11B, Paterna Valencia 46980, Spain

    Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, Valencia 46010, Spain

    Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Massachusetts, 02215 USA

    Department of Obstetrics and Gynecology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
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  • Diana Valbuena
    Affiliations
    Igenomix R&D, Parque Tecnológico de Paterna, Ronda Narciso Monturiol Estarriol 11B, Paterna Valencia 46980, Spain

    Igenomix Foundation, INCLIVA Health Research Institute, Parque Tecnológico de Paterna, Ronda Narciso Monturiol Estarriol 11B, Paterna Valencia 46980, Spain
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Published:November 17, 2021DOI:https://doi.org/10.1016/j.rbmo.2021.11.010

      ABSTRACT

      Research Question

      : Is there is a difference in clinical outcomes between day 5 versus day 6 blastocysts when transferred in a personalized embryo transfer (pET) cycle guided by Endometrial Receptivity Analysis (ERA)?

      Design

      : Multicentre, retrospective study; 260 patients who underwent a single embryo transfer (SET) with either a day 5 or day 6 blastocyst in a pET cycle guided by ERA between January 2017 and December 2019.

      Results

      : A total of 260 blastocysts were transferred in a single embryo pET cycle guided by ERA. Of those, 183 (70.4%) were day 5 blastocysts and 77 (29.6%) were day 6 blastocysts. Clinical outcomes were similar when transferring day 5 blastocysts versus day 6 blastocysts: pregnancy rate was 75.4% (138/183) and 70.1% (54/77) (P = 0.465), implantation rate was 67.8% (124/183) and 63.6% (49/77) (P = 0.476), and ongoing pregnancy rate was 57.9% (106/183) and 58.4% (45/77) (P = 0.728), respectively.

      Conclusions

      : Our data suggests that the clinical potential of day 5 and day 6 blastocysts are similar, as no difference in clinical outcomes are observed when transferring at the time of optimal endometrial receptivity as determined by ERA.

      Keywords

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      Biography

      Tiffany Stankewicz is currently pursuing her doctorate in genetics at the University of Kent in the UK. She began her career in IVF as an embryologist and now is a scientific advisor focusing primarily on endometrial health and implantation.
      Key Message
      This study showed no difference in clinical outcome when transferring day 5 versus day 6 blastocysts into a receptive endometrium, suggesting a similar clinical potential regardless of day of blastulation. Our findings further highlight the importance of personalized medicine and the need to identify other markers of embryo viability and potential.