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Association between Paternal age and subtypes of preterm birth: A retrospective study

  • Author Footnotes
    1 These authors contributed equally to this work.
    Yiting Mao
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China

    Shanghai Key Laboratory of Embryo Original Disease, Shanghai, China
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  • Author Footnotes
    1 These authors contributed equally to this work.
    Zhaonan Liu
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    The Key Laboratory of Reproductive Genetics (Zhejiang University), Ministry of Education, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
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  • Author Footnotes
    1 These authors contributed equally to this work.
    Chen Zhang
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China

    Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, 200011, China
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  • Yinyu Wang
    Affiliations
    The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China

    Shanghai Key Laboratory of Embryo Original Disease, Shanghai, China
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  • Yicong Meng
    Affiliations
    The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China

    Shanghai Key Laboratory of Embryo Original Disease, Shanghai, China
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  • Lei Chen
    Affiliations
    The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China
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  • Jianzhong Sheng
    Affiliations
    Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, China
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  • Yanting Wu
    Correspondence
    Prof. Yanting Wu: Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, No. 419 Fangxie Road, Shanghai, 200011, China.
    Affiliations
    Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, 200011, China
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  • Hefeng Huang
    Correspondence
    Correspondence: Prof. Hefeng Huang: The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No. 1961, Huashan Road, Shanghai 200030, China, Tel.: (021-64073897).
    Affiliations
    The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China

    Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, 200011, China

    Shanghai Key Laboratory of Embryo Original Disease, Shanghai, China

    The Key Laboratory of Reproductive Genetics (Zhejiang University), Ministry of Education, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
    Search for articles by this author
  • Author Footnotes
    1 These authors contributed equally to this work.
Published:December 20, 2021DOI:https://doi.org/10.1016/j.rbmo.2021.12.012

      Highlight

      • Advanced paternal age was associated with a higher risk of preterm birth and very early preterm birth (VPTB).
      • Advanced paternal age increased risk of preterm birth was associated mostly with the higher risk of preterm birth with premature rupture of membranes (PROM-PTB) and medically induced preterm birth (MI-PTB).
      • The maximum increase in the estimated odds ratio reached to 5.67 for preterm birth with premature rupture of membranes (PROM-PTB) was in fathers aged 35 to 44 years and mothers aged 20 to 24 years old who carried a male foetus.

      Abstract

      Research question

      : To determine whether advanced paternal age (APA) is associated with preterm birth as well as the subtype of preterm birth.

      Design

      : 66167 cases were enrolled. Linear regression model and logistic regression model were used to analyse the association between paternal age and subtypes of preterm birth.

      Results

      : Advanced paternal age was associated with a higher risk of preterm birth (35-44: OR, 1.16 [1.04 to 1.28], p=0.006; >44: OR, 1.40 [1.10 to 1.78], p=0.007) and very early preterm birth (VPTB) (<34 weeks) (35-44: OR, 1.46 [1.17 to 1.81], p=0.002; >44: OR, 1.65 [1.01 to 2.69], p=0.045). The increased risk of preterm birth was associated mostly with preterm birth with premature rupture of membranes (PROM-PTB) (35-44: OR, 1.23 [1.03 to 1.48], p=0.021) and medically induced preterm birth (MI-PTB) (>44: OR, 1.55 [1.12 to 2.15], p=0.008). Women who carried male foetuses in the 35-to-44-year-old paternal age group had a 1.29-fold risk of PROM-PTB (OR, 1.29 [1.02 to 1.63], p=0.031) and a 1.26-fold risk of MI-PTB (OR, 1.26 [1.04 to 1.52], p=0.017). No evidence showed a higher risk of PROM-PTB among women carrying a female foetus while a 1.67-fold higher risk of MI-PTB in the 45-or-older paternal age group was observed (OR, 1.67 [1.04 to 2.67], p=0.035).

      Conclusion

      : Our results suggest that APA is associated with a higher risk of preterm birth and VPTB, mainly concerned with PROM-PTB and MI-PTB. Our study also indicates a foetal sex-specific association between APA and a higher risk of PROM-PTB for those had male foetuses.

      Keywords

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      Biography

      Dr. Hefeng Huang has been working in reproductive medicine since 1990s. She has been awarded Academician of the Chinese Academy of Sciences, Third World Academy of Sciences, and Fellow Honoris Causa of the Royal College of Obstetricians and Gynecologists. Her research interests includes embryo and gamete originated health and disease.
      Key message
      This study found that advanced paternal age was associated with a higher risk of preterm birth and very early preterm birth (VPTB). The increased risk of preterm birth was associated mostly with the higher risk of preterm birth with premature rupture of membranes (PROM-PTB) and medically induced preterm birth (MI-PTB).