Does the oocyte donor's age affect live birth rate (LBR) in recipients?
Retrospective study of 3766 oocyte recipient cycles carried out between January 2009 and December 2018. Cycles were categorized into groups according to donor's age: <20 years (4.7%); 20–25 years (41.1%); ≥26 years (54.2%). Chi-squared test was used to evaluate differences in LBR and analysis of variance was used to test differences in embryo quality, and fertilization and embryo development rates. A generalized linear mixed model was applied to estimate the odds for each end point.
LBR was 40.7%. When analysed according to donors’ age, significant differences were found: 33.9% for the youngest group, 39.1% for the group aged 20–25 years, and 42.5% for donors aged ≥26 years (P = 0.022). When adjusting for confounding factors (recipient age, number of transferred embryos and day of embryo transfer), LBR was lower in the group aged <20 years (OR 0.70; CI 95% 0.50 to 0.99) and in the group aged 20–25 years (OR 0.85; CI 95% 0.74 to 0.98) compared with the group aged ≥26 years. No significant differences were observed in fertilization rates (74.2%, 76.1% and 77.5%) or embryo development rates (57.0%, 61.4% and 62.0%). The number of good-quality embryos transferred was significantly lower in the group aged <20 years (1.03 ± 0.71; 1.18 ± 0.69; 1.19 ± 0.67; P = 0.015).
LBR is significantly lower when donors are younger than 25 years and, especially, when they are younger than 20 years.
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Marta Roca-Feliu obtained her master's degree in reproductive biology and assisted human reproduction techniques from the Universitat Autònoma Barcelona and Institut Universitari Dexeus, 2016. She works for the Reproductive Medicine Service at Dexeus University Hospital, Barcelona. Her research interests are oocyte and embryo donation and ethics and psychology of donation.
Published online: January 28, 2022
Accepted: January 21, 2022
Received in revised form: January 14, 2022
Received: September 28, 2021Declaration: The authors report no financial or commercial conflicts of interest.
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