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Experience, and gynaecological and reproductive health follow-up of young adult women who have undergone ovarian tissue cryopreservation

      Abstract

      Research question

      What are the experience, and gynaecological and reproductive health outcomes in young adult women who have undergone ovarian tissue cryopreservation (OTC)?

      Design

      A retrospective observational study was conducted at a single institution between May 2019 and February 2021 including 87 women aged over 18 years undergoing OTC. Medical characteristics and questionnaire data collected more than 18 months after OTC were analysed.

      Results

      Close to 74% (n = 64/87) of women had a follow-up consultation and completed the questionnaire. Most women found the information provided on the OTC technique and the strategies proposed to restore fertility with ovarian tissue understandable and useful. The majority of patients thought that OTC had a positive impact on their well-being during disease treatment. Anti-Müllerian hormone serum concentration decreased significantly after treatment (P < 0.0001) and was significantly lower when patients received chemotherapy before OTC (P = 0.0039). The total cyclophosphamide equivalent dose was significantly higher in women with FSH concentrations above 25 IU/l after treatment (P = 0.0004). More than 70% of women who planned a pregnancy after the end of treatment succeeded, with a natural pregnancy rate close to 53%. Only nine patients (8.0%) underwent ovarian tissue transplantation for fertility restoration and six of them became pregnant and delivered at least once.

      Conclusion

      Young adult women expressed a good satisfaction rate with OTC and that their experience had been beneficial. The usage rate of cryopreserved ovarian tissue remains low. The gynaecological and reproductive health follow-up consultation should be included in the supportive care provided following OTC.

      Keywords

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      Biography

      Marine Leflon obtained a Medical Doctor degree at Normandy Rouen University in 2019 and also holds a specialization in Gynaecology and Reproductive Medicine. She works at the Reproductive Biology Laboratory-CECOS and Department of Gynecology and Obstetrics of Rouen University Hospital, with a main focus on female infertility.
      Key message
      Young women have a positive experience of ovarian tissue cryopreservation (OTC). However, the usage rate of cryopreserved ovarian tissue remains very low. The gynaecological and reproductive health follow-up consultation should be systematically included in the supportive care provided after OTC.