Abstract
Research Question
Can Gardner embryo grades be converted to numeric interval variables to improve the
incorporation of embryo grading in statistical analyses?
Design
An equation that can be used to convert Gardner embryo grades to regular interval
scale variables was developed: the numerical embryo quality scoring index (NEQsi).
The NEQsi system was then validated with a retrospective chart analysis including
IVF cycles (n=1711) conducted at a single Canadian fertility centre between 2014 -
2022. Gardner embryo grades on file were assigned using EmbryoScope and converted
to NEQsi scores. Descriptive statistics and univariate logistic regressions with pregnancy
outcome were prepared to demonstrate the relationship between NEQsi score and pregnancy
rate.
Results
The NEQsi method produces interval numerical scores that range from 2 – 11. Patient
case files in which single embryo transfers occurred (n = 1711) were examined and
the existing Gardner embryo grades on file were converted to NEQsi scores. NEQsi scores
ranged from 3 to 11 with a median of score of 9. A positive linear relationship existed
between the NEQsi scores and the probability of pregnancy. The NEQsi score was a significant
predictor of pregnancy (p<0.0001).
Conclusion
Gardner embryo grades can be converted to interval variables and used directly statistical
analyses.
Key Words
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Biography
Hannah Pierson earned her PhD in Biochemistry and completed her Post Doctoral Fellowship in Epithelial Cell Biology at the Johns Hopkins Medical Institute. She is currently a Senior Scientist with Synergyne ART Analytics Inc. Her research interests include advancing the boundaries of biomedical image interpretation technologies and the cellular dynamics of endometrium.
Article info
Publication history
Accepted:
January 8,
2023
Received in revised form:
December 22,
2022
Received:
August 19,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
