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A novel system for rapid conversion of Gardner embryo grades to linear scale numeric variables

  • Hannah E Pierson
    Affiliations
    Synergyne Imaging Technology, 518 Chotem Crescent, Saskatoon, Saskatchewan, Canada, S7N 4M4
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  • Jesse Invik
    Affiliations
    Synergyne Imaging Technology, 518 Chotem Crescent, Saskatoon, Saskatchewan, Canada, S7N 4M4
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  • Jim Meriano
    Affiliations
    TRIO Fertility Centre, 655 Bay Street, Toronto, Ontario, Canada, M5G 2K4
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  • Author Footnotes
    ⁎ Hannah Pierson and Jesse Invik are considered co-first authors
    Roger A. Pierson
    Correspondence
    Correspondence should be addressed to Roger A. Pierson MS PhD FEAS FCAHS, Postal Address: Obstetrics and Gynecology, University of Saskatchewan, College of Medicine, 103 Hospital Drive, Saskatoon, Saskatchewan, Canada, S7N 0W8
    Footnotes
    ⁎ Hannah Pierson and Jesse Invik are considered co-first authors
    Affiliations
    Obstetrics and Gynecology, University of Saskatchewan, College of Medicine, 103 Hospital Drive, Saskatoon, Saskatchewan, Canada, S7N 0W8
    Search for articles by this author
  • Author Footnotes
    ⁎ Hannah Pierson and Jesse Invik are considered co-first authors
Published:January 12, 2023DOI:https://doi.org/10.1016/j.rbmo.2023.01.008

      Abstract

      Research Question

      Can Gardner embryo grades be converted to numeric interval variables to improve the incorporation of embryo grading in statistical analyses?

      Design

      An equation that can be used to convert Gardner embryo grades to regular interval scale variables was developed: the numerical embryo quality scoring index (NEQsi). The NEQsi system was then validated with a retrospective chart analysis including IVF cycles (n=1711) conducted at a single Canadian fertility centre between 2014 - 2022. Gardner embryo grades on file were assigned using EmbryoScope and converted to NEQsi scores. Descriptive statistics and univariate logistic regressions with pregnancy outcome were prepared to demonstrate the relationship between NEQsi score and pregnancy rate.

      Results

      The NEQsi method produces interval numerical scores that range from 2 – 11. Patient case files in which single embryo transfers occurred (n = 1711) were examined and the existing Gardner embryo grades on file were converted to NEQsi scores. NEQsi scores ranged from 3 to 11 with a median of score of 9. A positive linear relationship existed between the NEQsi scores and the probability of pregnancy. The NEQsi score was a significant predictor of pregnancy (p<0.0001).

      Conclusion

      Gardner embryo grades can be converted to interval variables and used directly statistical analyses.

      Key Words

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      Biography

      Hannah Pierson earned her PhD in Biochemistry and completed her Post Doctoral Fellowship in Epithelial Cell Biology at the Johns Hopkins Medical Institute. She is currently a Senior Scientist with Synergyne ART Analytics Inc. Her research interests include advancing the boundaries of biomedical image interpretation technologies and the cellular dynamics of endometrium.