ABSTRACT
Research Question
What are health professionals’ clinical practice, views and self-rated competencies
regarding the transfer of mosaic embryos?
Design
Cross-sectional study using surveys
Results
Data were collected from the Royal Australian and New Zealand College of Obstetricians
and Gynaecologists and the Fertility Society of Australia and New Zealand. Ninety-five
responses were analysed and reported. Results show that most health professionals
(n = 62) discussed the transfer of mosaic embryos for different reasons and raised
concerns regarding various risks. Though many health professionals were unsure whether
mosaic embryos should be transferred, they were more inclined to encourage transfer
if the scenario involved segmental losses compared to mosaicism involving duplication
of the entire chromosome (i.e., trisomy 21) (e.g., ORdiscourage & S1 = .21, p = .00; ORencourage & S2 = 2.78, p = .04). The majority of health professionals would inform patients about the mosaicism
to facilitate informed decision-making. The factors that health professionals identified
as most important when discussing the transfer of mosaic embryos was specific chromosome
involved. Different self-rated competencies were found amongst health professionals
with different backgrounds.
Conclusion
Most health professionals were willing to discuss the mosaicism in the embryo with
patients to facilitate informed decision-making. However, health professionals’ uncertainty
towards the transfer of mosaic embryos indicated a lack of standardised transfer policy.
Also, obstetricians and gynaecologists and those with multiprofessional backgrounds
showed deficiencies in several self-rated competencies, suggesting that education
targeted to these groups is needed to optimise the quality of care of women considering
transfer of mosaic embryos.
Keywords
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Biography
Dr Lin Cheng obtained her PhD degree at Prince of Wales Clinical School, the University of New South Wales. Currently, she works as an implementation science research fellow at the University of Melbourne. Her research focuses on the implementation of genomic testing in various settings.
Article info
Publication history
Accepted:
February 20,
2023
Received in revised form:
February 10,
2023
Received:
September 14,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
