What are health professionals’ clinical practice, views and self-rated competencies regarding the transfer of mosaic embryos?
Cross-sectional study using surveys
Data were collected from the Royal Australian and New Zealand College of Obstetricians and Gynaecologists and the Fertility Society of Australia and New Zealand. Ninety-five responses were analysed and reported. Results show that most health professionals (n = 62) discussed the transfer of mosaic embryos for different reasons and raised concerns regarding various risks. Though many health professionals were unsure whether mosaic embryos should be transferred, they were more inclined to encourage transfer if the scenario involved segmental losses compared to mosaicism involving duplication of the entire chromosome (i.e., trisomy 21) (e.g., ORdiscourage & S1 = .21, p = .00; ORencourage & S2 = 2.78, p = .04). The majority of health professionals would inform patients about the mosaicism to facilitate informed decision-making. The factors that health professionals identified as most important when discussing the transfer of mosaic embryos was specific chromosome involved. Different self-rated competencies were found amongst health professionals with different backgrounds.
Most health professionals were willing to discuss the mosaicism in the embryo with patients to facilitate informed decision-making. However, health professionals’ uncertainty towards the transfer of mosaic embryos indicated a lack of standardised transfer policy. Also, obstetricians and gynaecologists and those with multiprofessional backgrounds showed deficiencies in several self-rated competencies, suggesting that education targeted to these groups is needed to optimise the quality of care of women considering transfer of mosaic embryos.
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Dr Lin Cheng obtained her PhD degree at Prince of Wales Clinical School, the University of New South Wales. Currently, she works as an implementation science research fellow at the University of Melbourne. Her research focuses on the implementation of genomic testing in various settings.
Accepted: February 20, 2023
Received in revised form: February 10, 2023
Received: September 14, 2022
Publication stageIn Press Journal Pre-Proof
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