ABSTRACT
Research question
To investigate which factors impact on clinical pregnancy rate (CPR) and live birth
rates (LBR) in euploid frozen embryo transfer (eFET) cycles.
Design
Retrospective observational study including 1660 eFET cycles with 2439 euploid blastocysts,
from November 2016 to December 2020. The impact of clinical and laboratory parameters
on CPR, biochemical miscarriage rate (BMR), clinical miscarriage rate (CMR) and LBR
was evaluated.
Results
CPR per transfer was 63.4%, LBR per transfer 51.6%. CPR and LBR were significantly
higher when double embryo transfer (DET) was performed (71.5% vs 57.7%,p<0.001;55.1% vs 49.1%,p=0.016, respectively). However, pregnancy loss was significantly higher in DET group
(28.8% vs 22.8%,p=0.02). When patients were classified by BMI, no differences were observed for CPR,
but CMR was lower (p<0.001) and LBR higher (p<0.031) for normal BMI group. Natural cycle (NC) protocol revealed lower CMR (p<0.001) and lower pregnancy loss (p<0.001); subsequently, higher LBR (57.6%,48.8%,45%,p=0.001) compared to hormonal replacement protocol and stimulated cycle. Day of trophectoderm
biopsy affected CPR (p<0.001) and LBR (<0.001), yet no differences were observed for BMR, CMR nor pregnancy
loss. The multivariate analysis showed that day 6/7 embryos had lower probabilities
for pregnancy; overweight and obesity had a negative impact on LBR, and NC improved
LBR.
Conclusion(s)
Day of biopsy affected CPR, while BMI and endometrial preparation protocol were associated
with LBR in eFET. DET should be discouraged as it will increase the risk of pregnancy
loss. Women with higher BMI should be aware of higher risk of pregnancy loss and lower
LBR although an euploid blastocyst is transferred.
Key words
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Biography
Dr Laura Melado graduated as MD in 2002 (Universidad Autónoma in Madrid), where she completed her Doctoral dissertation on ¨AMH during controlled ovarian stimulation¨ with Cum Laude (2015) and she worked as Ob/Gyn/IVF Specialist in Spain. Nowadays, she is the Medical Director at ART Fertility Clinics Abu Dhabi, UAE.
Article info
Publication history
Accepted:
February 27,
2023
Received in revised form:
January 3,
2023
Received:
September 25,
2022
Publication stage
In Press Journal Pre-ProofFootnotes
Declarations of interest: none
Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Identification
Copyright
© 2023 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
