ABSTRACT
Research question
Do morphokinetic parameters vary between male and female preimplantation embryos?
Design
Retrospective cohort study of 175 cycles between March 2018 to June 2021 from two
reproductive centers. It included time-lapse data from 92 female and 83 male preimplantation
embryos exclusively issued from fresh oocyte donation. Only fresh elective single-embryo
transfers on day 5 were assessed and sex of the embryo was confirmed at birth. The
morphokinetic parameters analyzed were measured in hours post insemination. A two-tailed
Student's t-test was used to compare morphokinetics between embryo sexes and a p<0.05 was considered statistically significant.
Results
Following strict inclusion criteria to avoid poor quality preimplantation embryos,
no significant differences were found in morphokinetic parameters when comparing cycles
that resulted in female vs. male live births: time to pronuclear fading (21.8±3.3
vs. 22.3±3.4 hpi; p>0.39); time to 2-cell stage (24.6±2.5 vs. 25.0±2.5 hpi; p>0.34); time to 3-cell stage (35.3±3.3 vs. 35.8±3.1 hpi; p>0.28); time to 4-cell stage (36.3±3.4 vs. 36.9±3.7 hpi; p>0.20); time to 5-cell stage (47.9±4.7 vs. 48.0±4.8 hpi; p>0.88); time to 8-cell stage (54.0±6.5 vs. 54.1±6.5 hpi; p>0.91); time to start of blastulation (86.3±14.6 vs 85.7±15.5 hpi; p>0.78) and time to full blastocyst stage (93.0±16.9 vs. 93.2±17.2 hpi; p>0.94).
Conclusion
There are no significant differences in morphokinetics between male and female preimplantation
embryos
KEYWORDS
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Biography
Juanjo Fraire-Zamora received a Biology degree from UNAM (Mexico), a PhD from University of California (USA) and a Master's degree in Human Assisted Reproductive Technologies from UPF (Spain). He is part of the data team at the EUGIN group and an active member of ESHRE.
Article info
Publication history
Accepted:
March 2,
2023
Received in revised form:
February 10,
2023
Received:
November 29,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
