ABSTRACT
Research question
Can ovarian reserve parameters predict outcome of ovarian tissue cryopreservation
(OTCP) in patients ≤ 18 years with non-iatrogenic premature ovarian insufficiency
(POI)?
Design
A retrospective cohort analysis carried out in a single tertiary hospital between
August 2010 and January 2020. 37 patients ≤ 18 years with non-iatrogenic POI (27 with
Turner syndrome, six with POI of unknown etiology, three with Galactosemia and one
with Blepharophimosis-Ptosis-Epicanthus-inversus syndrome) were included. Three parameters
were used to evaluate ovarian reserve: Anti-Müllerian hormone (AMH), Follicle-stimulating
hormone (FSH) and trans-abdominal antral follicle count. Fertility preservation (most
commonly OTCP) was offered if ovarian reserve was diminished and ≥1 parameter was
positive. Follicles were counted in ovarian samples obtained at the time of OTCP.
Results
Ovarian reserve was diminished in 34 patients and 19 of them had ≥1 positive parameter.
Fourteen (11 ≥12 years and three <12) underwent OTCP, one (14 years old) underwent
controlled ovarian hyper-stimulation and oocyte cryopreservation and four declined
fertility preservation. Follicles were detected in 11 of 14 patients who underwent
OTCP (79%), and in all those (100%) who had 2 or 3 positive parameters. The median
number of follicles was 27 (range 5-64) and 48 (range 21-75) in patients ≥12 years
and those <12 respectively.
Conclusion
This study shows that if OTCP is performed in patients with ≥1 positive parameter
of ovarian activity, a 79% positive predictive value is achieved for the detection
of follicles. The incorporation of this criterion for OTCP will minimize the risk
of harvesting ovarian tissue with a low number of follicles.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Reproductive BioMedicine OnlineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
Biography
Michal Zajicek is the head of Gynecological Ultrasound service at the Institute of Obstetrics and Gynecological Imaging, Sheba Medical Center, Israel. Her research focuses on gynecological ultrasound. Special interest in endometriosis, fertility work-up, hydro-sonography and hystero-salpingo-sonography, Mülerian anomalies and gynecological malignancies.
Article info
Publication history
Accepted:
March 6,
2023
Received in revised form:
February 10,
2023
Received:
October 29,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
