Abstract
Research Question
What is the impact of dietary habits on ovarian response to hyperstimulation? Can
preconception adherence to the Mediterranean diet influence the rate of poor ovarian
response? The impact of dietary habits on the success of IVF is controversial. Inconsistencies
may be explained by confounders associated to the use of pregnancy as an outcome as
well as by a reductionist view of diet that focuses on single components rather than
on food patterns.
Design
This cross-sectional study analyzed the adherence to the Mediterranean diet in women
with unexpected poor response to ovarian hyperstimulation. Main inclusion criteria
were the following: age 18-39 years, normal weight, preserved ovarian reserve and
starting dose of gonadotropins of 150-225 IU/day. The adherence to the Mediterranean
diet was assessed through a Mediterranean Diet Score (MDS). Unexpected poor ovarian response was defined as the retrieval of ≤3 suitable oocytes.
Results
Three hundred and three women were included, of whom 48 (16%) showed an unexpected
poor response. We did not observe a frank dose related association with tertiles of
MDS at univariate analysis. However, at multivariate analysis, the risk of unexpected
poor response was significantly lower for women in the second tertile of MDS compared
to the first tertile (adjusted OR=0.29, 95%CI: 0.11-0.76) and for women in the second
and third tertile, grouped together, compared to the first one (adjusted OR=0.34,
95%CI: 0.14-0.82).
Conclusions
Low adherence to Mediterranean diet could be a as risk factor for unexpected poor
response.
Keywords
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Biography
Stefania Noli graduated in Medicine at the University of Milan, Italy, in 2010. She completed her residency in Obstetrics and Gynecology at the same University in 2016. She works as clinical researcher of the University of Milan, at the Infertility Unit of the Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico.
Article info
Publication history
Accepted:
March 10,
2023
Received in revised form:
March 9,
2023
Received:
November 3,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
