- Although significant strides have been made in the last 40 years, the mean pregnancy rate after an IVF cycle still hovers around 30%, with a 20% chance of delivery (De Geyter et al., 2018). An important requisite to the success of an IVF cycle is the availability of a certain number of mature oocytes (metaphase III [MII]); usually obtained after ovarian stimulation.
- Does ovarian stimulation for oocyte vitrification affect disease-free survival and overall survival rates in women with early breast cancer?
- Conception via assisted reproductive technology (ART) increases the risk of type 2 diabetes and cardiovascular disease in adulthood. Underlying differences between ART-conceived and in-vivo-conceived embryos that contribute to this increased risk are, however, not known.
- In nature, HCG is secreted by the implanting embryo from peri-implantation and onwards. In contrast, LH is mandatory for steroidogenesis and follicular development during the follicular phase, working in synergy with FSH. Moreover, LH is mandatory for the function of the corpus luteum. Although LH and HCG bind to the same receptor, significant molecular, structural and functional differences exist, inducing differences in bioactivity. This randomized controlled study compared the effect of recombinant FSH stimulation combined with daily either micro-dose recombinant HCG or recombinant LH supplementation in a 1:1 bioactivity ratio from day 1 of stimulation in a long gonadotrophin releasing hormone agonist down regulation protocol.