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Ovulation induction using sequential letrozole/gonadotrophin in infertile women with PCOS: a randomized controlled trial
Polycystic ovary syndrome (PCOS) is the most common ovarian endocrine disease in women of reproductive age (Conway et al., 2014), with an incidence among premenopausal women of up to 20% when applying Rotterdam criteria (Yildiz et al., 2012). Oligo-ovulation is the most important and classic clinical manifestation of PCOS (Escobar-Morreale, 2018), and the resulting infertility is the major cause of anovulatory infertility (Balen and Michelmore, 2002), which affects many infertile women of reproductive age.Does underlying infertility in natural conception modify the epigenetic control of imprinted genes and transposable elements in newborns?
Does the epigenetic control of imprinted genes and transposable elements at birth differ according to time to conception in natural conception and after intrauterine insemination (IUI)?
