- Premature ovarian insufficiency (POI), defined as loss of normal ovarian functions before the age of 40 years, occurs in at least 1% of all women. It affects the reproductive system and causes many health problems and psychological stress. Abnormal serum lipid profile leads to cardiovascular diseases, which are strongly associated with high mortality in patients with POI. To date, several studies have examined the levels of different serum lipids in patients with POI. The results, however, are either inconclusive or inconsistent.
- Of all clinically recognized pregnancies, about 15% end in loss (Nybo Andersen et al., 2000; Rai and Regan, 2006). The great majority of pregnancy losses occur within the first trimester of pregnancy (Baird, 2009; Farr et al., 2007). Aneuploidy of the embryo is an important female age-related genetic cause of pregnancy loss and can be tested in pregnancy loss tissue (Hassold and Hunt, 2001; Rai and Regan, 2006). A proportion of couples (1–3%) not only suffer from one ‘sporadic’ pregnancy loss but from recurrent pregnancy loss, meaning two or more pregnancy losses (historically three or more losses) (Ford and Schust, 2009).
- Is there any genetic association between oestrogen receptor alpha [ERα]-PvuII polymorphism and idiopathic male infertility?