- What is the effect of letrozole use in patients undergoing frozen embryo transfer (FET) with normal ovulation? Although the number of FETs is increasing, an optimal protocol for FET (particularly vitrified–warmed embryo transfer) is yet to be determined. The aim of this study was to evaluate letrozole use on patients with normal menstrual cycles compared with hormone replacement therapy (HRT) cycles and natural cycles.
- Frozen–thawed embryo transfer (FET) has increased steadily worldwide over the past few years (De Geyter et al., 2020; Zegers-Hochschild et al., 2020). In 2015, FET accounted for about 40% of all IVF cycles in Europe (De Geyter et al., 2020). The freeze-all strategy has reported successful results with higher live birth rates and lower incidence of ovarian hyperstimulation syndrome compared with fresh embryo transfer (Roque et al., 2019; Wei et al., 2019). Some studies have suggested that singletons born after FET also have better neonatal outcomes compared with singletons born after fresh embryo transfer, e.g.
- This cohort study assessed whether timing therapeutic donor sperm inseminations (TDI) in natural cycles (NC) using ultrasound monitoring and ovulation trigger with human chorionic gonadotrophin (US/HCG) improves cumulative live birth rates (LBR) compared with detection of LH surge with urinary kits (u-LH). It included 232 normo-ovulatory women aged ≤40 years, undergoing 538 TDI in NC between 2011 and 2014. In the u-LH group (113 women, 267 cycles), TDI was performed the day following a positive test.