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Spatial and temporal changes in follicle distribution in the human ovarian cortex
How does follicle distribution evolve in the human ovarian cortex between the ages of 20 and 35 years?miR-532-3p: a possible altered miRNA in cumulus cells of infertile women with advanced endometriosis
Is the profile of microRNA (miRNA) altered in cumulus cells of infertile women with early (EI/II) and advanced (EIII/IV) endometriosis?An artificial intelligence model based on the proteomic profile of euploid embryos and blastocyst morphology: a preliminary study
The two main factors responsible for the success of an IVF treatment are the endometrium and the embryo (Edwards et al., 1984). Non-invasive methods (morphological and morphokinetic) as well as invasive methods (genetic testing) are currently used in IVF laboratories in embryo selection. However, new approaches to select embryos are still being investigated due to the limited improvement in live birth rate over the last few years (Dyer et al., 2016; De Geyter et al., 2018).Do fertility tracking applications offer women useful information about their fertile window?
To characterize mobile fertility tracking applications (apps) to determine the use of such apps for women trying to conceive by identifying the fertile window.A revolutionary joins the establishment: Reproductive Biomedicine Online turns 20
This commentary highlights the publishing revolution achieved by Robert Edwards in founding Reproductive Biomedicine Online. It corrects some inaccuracies in the account given by Roger Gosden in his recently published book Let There Be Life: An Intimate Portrait of Robert Edwards and His IVF Revolution.Same-sex male couples and single men having children using assisted reproductive technology: a quantitative analysis
How do same-sex male couples (SSMC) and single men perceive their experience of using assisted reproductive technology (ART) in Canada; what factors contribute to their experience and the decisions made throughout the ART process?The prevalence, promotion and pricing of three IVF add-ons on fertility clinic websites
How are IVF clinic websites advertising three common IVF add-ons: assisted hatching, time-lapse embryo imaging and preimplantation genetic testing for aneuploidies (PGT-A)?Empathetic application of machine learning may address appropriate utilization of ART
The value of artificial intelligence to benefit infertile patients is a subject of debate. This paper presents the experience of one aspect of artificial intelligence, machine learning, coupled with patient empathy to improve utilization of assisted reproductive technology (ART), which is an important aspect of care that is under-recognized. Although ART provides very effective options for infertile patients to build families, patients often discontinue ART when further treatment is likely to be beneficial and most of these patients do not achieve pregnancy without medical aid.Candidate genes for age at menarche are associated with endometriosis
Are the candidate genes for age at menarche associated with a risk of endometriosis?The performance of the Elecsys® anti-Müllerian hormone assay in predicting extremes of ovarian response to corifollitropin alfa
What is the performance of anti-Müllerian hormone (AMH) as measured by the Elecsys® AMH assay in predicting ovarian response in women treated with 150 µg corifollitropin alfa (CFA)?Maternal and perinatal outcomes in programmed versus natural vitrified–warmed blastocyst transfer cycles
Do maternal and perinatal outcomes differ between natural and programmed frozen embryo transfer (FET) cycles?Cytogenetic testing of pregnancy loss tissue: a meta-analysis
Of all clinically recognized pregnancies, about 15% end in loss (Nybo Andersen et al., 2000; Rai and Regan, 2006). The great majority of pregnancy losses occur within the first trimester of pregnancy (Baird, 2009; Farr et al., 2007). Aneuploidy of the embryo is an important female age-related genetic cause of pregnancy loss and can be tested in pregnancy loss tissue (Hassold and Hunt, 2001; Rai and Regan, 2006). A proportion of couples (1–3%) not only suffer from one ‘sporadic’ pregnancy loss but from recurrent pregnancy loss, meaning two or more pregnancy losses (historically three or more losses) (Ford and Schust, 2009).Prospective randomized multicentre comparison on sibling oocytes comparing G-Series media system with antioxidants versus standard G-Series media system
Does the inclusion of three antioxidants (A3), acetyl-l-carnitine (ALC), N-acetyl-l-cysteine (NAC) and alpha-lipoic acid (ALA) improve human embryo development and pregnancy potential?Durations of intrauterine balloon therapy and adhesion reformation after hysteroscopic adhesiolysis: a randomized controlled trial
Does placing an intrauterine balloon for different durations (7, 14 or 28 days) affect the recurrence of intrauterine adhesions after hysteroscopic adhesiolysis?Context-based infertility care
Over the last few months we have reflected in these pages on a number of challenging issues that need to be addressed if clinical research in our field is to continue to impact on day-to-day infertility care (Macklon et al., 2019; Fauser and Macklon, 2019). As articulated by others (Horwitz et al 2017; Kent et al. 2018), we have argued that limiting clinical practice to only those interventions that have been shown to be ‘effective’ for a group of patients included in randomized controlled trials (RCTs) threatens to prevent rather than encourage the development of a clinically useful evidence-based medicine (EBM) for individual patients.Identification of research priorities in infertility and assisted reproduction: an international, multicentre study
What are the main research interests among patients of assisted reproductive technologies (ART)?‘There is only one thing that is truly important in an IVF laboratory: everything’ Cairo Consensus Guidelines on IVF Culture Conditions
This proceedings report presents the outcomes from an international expert meeting to establish consensus guidelines on IVF culture conditions. Topics reviewed and discussed were: embryo culture – basic principles and interactions; temperature in the IVF laboratory; humidity in culture; carbon dioxide control and medium pH; oxygen tension for embryo culture; workstations – design and engineering; incubators – maintaining the culture environment; micromanipulation – maintaining a steady physcochemical environment; handling practices; assessment practices; culture media – buffering and pH, general composition and protein supplementation, sequential or single-step media for human embryo culture; use and management – cold chain and storage; test equipment – calibration and certification; and laboratory equipment and real-time monitoring.Risk factors associated with pre-eclampsia in pregnancies conceived by ART
What are the factors associated with the increased incidence of pre-eclampsia in pregnancies conceived through IVF using autologous oocytes?Ovarian stimulation for oocyte vitrification does not modify disease-free survival and overall survival rates in patients with early breast cancer
Does ovarian stimulation for oocyte vitrification affect disease-free survival and overall survival rates in women with early breast cancer?Controversies in ART: can the IVF laboratory influence preimplantation embryo aneuploidy?
Published reports have indicated that rates of preimplantation embryo aneuploidy in a control donor population may vary between IVF centres. This suggests that location-specific conditions, in the clinic, IVF or genetics laboratory, may be influencing the chromosome dynamics or diagnosis. More recent reports suggest that rates of embryo mosaicism, representing mitotic errors, may vary between IVF centres. This would suggest perhaps a laboratory-controlled variable is influencing mitotic cell division during preimplantation embryo development.Use of progestins to inhibit spontaneous ovulation during ovarian stimulation: the beginning of a new era?
Advances in oocyte and embryo cryopreservation for assisted reproduction prompted new approaches to ovarian stimulation. Attention has been paid to progesterone and its derivatives to block the LH surge, as oocyte vitrification removes possible harmful effects of progestins on endometrial receptivity. This review summarizes the current status of progestin use to inhibit ovulation during ovarian stimulation compared with conventional ovarian stimulation. Progestin-primed ovarian stimulation is shown to effectively inhibit spontaneous ovulation, without affecting the number of retrieved oocytes and embryo quality.Childbirth close to natural menopause: does age at menopause matter?
Does a successful spontaneous pregnancy in the years close to natural menopause depend on age at menopause?Differential impacts of gonadotrophins, IVF and embryo culture on mouse blastocyst development
Conception via assisted reproductive technology (ART) increases the risk of type 2 diabetes and cardiovascular disease in adulthood. Underlying differences between ART-conceived and in-vivo-conceived embryos that contribute to this increased risk are, however, not known.Human growth hormone for poor responders: a randomized placebo-controlled trial provides no evidence for improved live birth rate
Does the addition of human growth hormone (HGH) to an IVF cycle improve the live birth rate in previously documented poor responders to FSH?Protective effect of oestrogen receptor α-PvuII transition against idiopathic male infertility: a case-control study and meta-analysis
Is there any genetic association between oestrogen receptor alpha [ERα]-PvuII polymorphism and idiopathic male infertility?
