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Oocyte developmental competence and embryo development: impact of lifestyle and environmental risk factors
Reproductive BioMedicine Online
Vol. 22Issue 5p410–420Published online: November 22, 2010
- Alex C. Varghese
- Kim D. Ly
- Cresandra Corbin
- Jaime Mendiola
- Ashok Agarwal
Cited in Scopus: 12
Oocyte development is the end result of a sophisticated biological process that is hormonally regulated and produced by highly specialized cellular lines that differentiate in early embryo/fetal development. Embryo development is initially regulated by maternal transcripts until replaced by embryonic genomic expression. Then, an assortment of hormones and local environmental factors in various concentrations along the reproductive tract (e.g. fallopian tube, endometrial lining) provide the protection, nutrients and means of communication for the embryo to implant and develop.