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Is there an association between oocyte number and embryo quality? A systematic review and meta-analysis
The aim of assisted reproduction technology (ART) is to help an infertile couple have a healthy baby born at term. Multifollicular growth induced by ovarian stimulation can lead to the collection of multiple oocytes, which, in turn, seems to increase pregnancy chances after ART. Hence, clinicians have for years been trying to obtain an adequate number of oocytes while minimizing the risk of ovarian hyperstimulation syndrome. Some have advocated that a higher number of collected oocytes is associated with improved outcomes (Baker et al., 2015; Macklon et al., 2006; van der Gaast et al., 2006).Anti-Müllerian hormone kinetics in pregnancy and post-partum: a systematic review
The aim of this systematic review is to critically appraise the available evidence regarding the kinetics of anti-Müllerian hormone (AMH) during pregnancy and post-partum. A systematic literature search was conducted in MEDLINE, Embase, CENTRAL, Scopus and Web of Science on 14 December 2015, aiming to identify studies providing data on the serum concentration of AMH in women at various stages of gestation and post-partum. There was a total of 1719 participants across eight studies. Seven out of the eight studies reported a decline in serum AMH concentration with advancing gestational age.To pill or not to pill in GnRH-antagonist cycles: the answer is in the data already!
The planning of IVF treatment by scheduling menstruation and hence initiation of ovarian stimulation using sex-steroid pre-treatment is commonly used. Pooling data from six randomized-controlled trials encompassing 1343 patients, with and without combined oral contraceptive pill pre-treatment, suggests that the ongoing pregnancy rate per randomized woman is significantly lower in patients with oral contraceptive pill pre-treatment (relative risk [RR]: 0.80, 95% confidence interval [CI]: 0.66–0.97; rate difference [RD]: −5%, 95% CI: −10% to −1%; fixed effects model).Clinical implications of congenital uterine anomalies: a meta-analysis of comparative studies
The clinical implications of congenital uterine anomalies (CUA), and the benefits of hysteroscopic resection of a uterine septum, were evaluated. Studies comparing reproductive and obstetric outcome of patients with and without CUA and of patients who had and had not undergone hysteroscopic resection of a uterine septum, were evaluated. Meta-analysis of studies indicated that the pregnancy rate was decreased in women with CUA (RR 0.85, 95% CI 0.73 to 1.00; marginally significant finding, P = 0.05).
