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Can time-lapse parameters predict embryo ploidy? A systematic review
Reproductive BioMedicine OnlineVol. 36Issue 4p380–387Published online: February 1, 2018- Arnaud Reignier
- Jenna Lammers
- Paul Barriere
- Thomas Freour
Cited in Scopus: 41Embryo morphology assessment performs relatively poorly in predicting implantation. Embryo aneuploidy screening (PGS) has recently improved, but its clinical value is still debated, and the development of a cheap non-invasive method for the assessment of embryo ploidy status is a highly desirable goal. The growing implementation of time-lapse devices led some teams to test the effectiveness of morphokinetic parameters as predictors of embryo ploidy, with conflicting results. The aim of this study was to conduct a comprehensive review of the literature on the predictive value of morphokinetic parameters for embryo ploidy status. - Commentary
Counselling considerations for chromosomal mosaicism detected by preimplantation genetic screening
Reproductive BioMedicine OnlineVol. 34Issue 4p369–374Published online: January 14, 2017- Andria G. Besser
- Emily L. Mounts
Cited in Scopus: 32The evolution of preimplantation genetic screening (PGS) for aneuploidy to blastocyst biopsy and more sensitive 24-chromosome screening techniques has resulted in a new diagnostic category of PGS results: those classified as mosaic. This diagnosis presents significant challenges for clinicians in developing policies regarding transfer and storage of such embryos, as well as in providing genetic counselling for patients prior to and following PGS. Given the high frequency of mosaic PGS results and the wide range of possible associated outcomes, there is an urgent need to understand how to appropriately counsel patients regarding such embryos.
