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Fetal growth disorders following medically assisted reproduction: due to maternal context or techniques? A national French cohort study
More than 8 million children are born worldwide following treatment with assisted reproductive technologies (ART) (Fauser, 2019), which corresponds to 3–5% of children born each year (Wyns et al., 2020), and child health remains a concern for reproductive specialists. Expansion of the policy of single embryo transfer following IVF has led to a reduction in complications induced by multiple pregnancies (Bergh et al., 2020; Spangmose et al., 2020). Nevertheless, perinatal outcomes following a single pregnancy obtained by ART appear to be less favourable than in natural conception (Pandey et al., 2012), and could depend on the technique used.Non-invasive evaluation of embryos using mid-infrared attenuated total reflection spectrometry of incubation medium: a preliminary study
Can mid-infrared attenuated total reflection (MIR ATR) spectroscopy combined with machine learning methods be used as an additional tool to predict embryo quality and IVF treatment outcomes?Birefringence properties of human immotile spermatozoa and ICSI outcome
As recently acknowledged by the World Health Organization (WHO), male infertility is a global health issue affecting millions of couples and individuals ( https://www.who.int/news-room/fact-sheets/detail/infertility ). There is currently a ubiquitous decline in natural fertility and a significant increase in the use of medically assisted reproduction (MAR) as a strategy to overcome the problems with conceiving (Skakkebæk et al., 2022). Advanced female age consequent to delayed childbearing (Choi et al., 2022), as well as a higher incidence of male infertility, are the most common indications for MAR treatment (Jafari et al., 2021).Does embryo categorization by existing artificial intelligence, morphokinetic or morphological embryo selection models correlate with blastocyst euploidy rates?
Does embryo categorization by existing artificial intelligence (AI), morphokinetic or morphological embryo selection models correlate with blastocyst euploidy?Ovulation induction using sequential letrozole/gonadotrophin in infertile women with PCOS: a randomized controlled trial
Polycystic ovary syndrome (PCOS) is the most common ovarian endocrine disease in women of reproductive age (Conway et al., 2014), with an incidence among premenopausal women of up to 20% when applying Rotterdam criteria (Yildiz et al., 2012). Oligo-ovulation is the most important and classic clinical manifestation of PCOS (Escobar-Morreale, 2018), and the resulting infertility is the major cause of anovulatory infertility (Balen and Michelmore, 2002), which affects many infertile women of reproductive age.An interpretable machine learning model for individualized gonadotrophin starting dose selection during ovarian stimulation
Can we develop an interpretable machine learning model that optimizes starting gonadotrophin dose selection in terms of mature oocytes (metaphase II [MII]), fertilized oocytes (2 pronuclear [2PN]) and usable blastocysts?Comparison of embryo implantation potential between time-lapse incubators and standard incubators: a randomized controlled study
Although millions of children have been conceived using assisted reproductive technology (ART), many aspects of the laboratory environment for IVF are not fully optimized (Griesinger, 2020). The incubators play a pivotal role in providing an appropriate embryo culture environment in the IVF laboratory (Swain, 2014). Traditionally, embryo culture during assisted reproduction uses standard incubators, from which embryos are removed daily for morphological assessment using conventional microscopy (Armstrong et al., 2019).PRSS55 is a novel potential causative gene for human male infertility
Testis-specific PRSS55 is a chymotrypsin-like serine protease that is highly conserved among mammalian species. The essential role of Prss55 in mouse male fertility has been established. What is the role of PRSS55 in human reproduction?Modelling the equilibrium partitioning of low concentrations of airborne volatile organic compounds in human IVF laboratories
Can volatile organic compounds (VOC) be modelled in an IVF clinical setting?Impact of empathic physician contact on patient anxiety and distress during the waiting period after embryo transfer: a randomized controlled trial
There is a high prevalence of anxiety and depression in patients with infertility (Chen et al., 2004; Pasch et al., 2016; Volgsten et al., 2008). Specific triggers include the infertility workup, receiving a specific diagnosis, ovarian stimulation injections, surgical procedures and waiting for the pregnancy test result after treatment cycles (Turner et al., 2013). High levels of anxiety and depression may cause patients to discontinue treatment because of the increased emotional burden associated with infertility treatment (Domar et al.Computer software (SiD) assisted real-time single sperm selection associated with fertilization and blastocyst formation
Is it possible to explore an association between individual sperm kinematics evaluated in real time and spermatozoa selected by an embryologist for intracytoplasmic sperm injection (ICSI), with subsequent normal fertilization and blastocyst formation using a novel artificial vision-based software (SiD V1.0; IVF 2.0, UK)?Periconceptional maternal social, lifestyle and medical risk factors impair embryonic growth: The Rotterdam Periconceptional Cohort
What is the association between the degree of a state of maternal vulnerability, determined by suboptimal periconceptional social, lifestyle and medical exposures and embryonic growth?Recipient outcomes in an oocyte donation programme: should very young donors be excluded?
Does the oocyte donor's age affect live birth rate (LBR) in recipients?Artificially prepared vitrified–warmed embryo transfer cycles are associated with an increased risk of pre-eclampsia
What is the association between the development of pre-eclampsia and endometrial preparation prior to vitrified–warmed embryo transfer (frozen embryo transfer, FET)?Low serum progesterone affects live birth rate in cryopreserved blastocyst transfer cycles using hormone replacement therapy
Does serum progesterone concentration on the day of vitrified–warmed embryo transfer affect live birth rate (LBR) with hormonal replacement therapy (HRT) cycles?Artificial intelligence in the embryology laboratory: a review
The goal of an IVF cycle is a healthy live-born baby. Despite the many advances in the field of assisted reproductive technologies, accurately predicting the outcome of an IVF cycle has yet to be achieved. One reason for this is the method of selecting an embryo for transfer. Morphological assessment of embryos is the traditional method of evaluating embryo quality and selecting which embryo to transfer. However, this subjective method of assessing embryos leads to inter- and intra-observer variability, resulting in less than optimal IVF success rates.Comparison of fresh and frozen ejaculated spermatozoa in sibling oocyte recipient cycles
Do IVF and intracytoplasmic sperm injection cycles using fresh and frozen ejaculated spermatozoa result in similar pregnancy outcomes in couples with non-male factor infertility?Treatment of symptomatic uterine adenomyosis with linzagolix, an oral gonadotrophin-releasing hormone antagonist: a pilot study
Does a once-daily regimen of linzagolix, a new oral gonadotrophin-releasing hormone (GnRH) antagonist, given at a fully suppressive dose (200 mg) for 12 weeks, followed by a partially suppressive dose (100 mg) for a further 12 weeks, reduce adenomyotic uterine size and associated symptoms?‘Why have women not returned to use their frozen oocytes?’: a 5-year follow-up of women after planned oocyte cryopreservation
What are the reproductive choices and retrospective reflections of women at least 4 years after planned oocyte cryopreservation (POC)?Childhood growth of term singletons born after frozen compared with fresh embryo transfer
Is the growth of term singletons born after frozen embryo transfer (FET) comparable to those born after fresh embryo transfer and natural conception up to 5 years of age?Learning from incidents in medically assisted reproduction: the Notify Library as a learning tool
Biovigilance is the systematic monitoring of serious adverse reactions and events (SARE) that ensures the quality and safety of tissues and cells for human application in medically assisted reproduction (MAR). The Notify Library is an open access database launched by the World Health Organization and supported by the Italian National Transplant Centre (CNT) that has collected information on documented adverse occurrences in transplantation, transfusion and MAR. It is not a SARE register, but rather a collection of SARE types identified primarily by review of published articles and case reports from national or regional vigilance programmes.Maternal body mass index associates with blastocyst euploidy and live birth rates: the tip of an iceberg?
Does maternal preconceptional body mass index (BMI) associate with mean blastocyst euploidy rate (m-ER) per patient and live birth rate (LBR) after vitrified–warmed euploid single embryo transfer (SET)?Vitrification with microinjection of single seminiferous tubules: an efficient cryopreservation approach for limited testicular tissue
Is vitrification with microinjection of single seminiferous tubules an efficient cryopreservation approach for limited testicular tissue?Cumulus cells of euploid versus whole chromosome 21 aneuploid embryos reveal differentially expressed genes
Can cumulus cells be used as a non-invasive target for the study of determinants of preimplantation embryo quality?
